A liquid-cooled plate with low thermal resistance, low-pressure loss and uniform temperature is important to guarantee the range of the power battery pack and delay the decay of cell life. To improve the heat transfer performance of the liquid-cooled plate, a power battery pack liquid-cooled plate was used as the object, the temperature uniformity coefficient was constructed, and a new full-featured disturbance element model was proposed. The characteristic parameters and arrangement parameters of the disturbance element were optimized, and a liquid-cooled plate heat transfer experimental rig was built to verify the accuracy of the simulation results of the temperature and pressure drop. Results showed that when the ratio of width to length of the disturbance element structure was 1, the ratio of disturbance element structure width to runner width was 0.5, and the interval between two disturbance elements was 15 mm, the comprehensive performance of the liquid-cooled plate was optimal. After optimization, the temperature uniformity coefficient of the liquid-cooled plate was reduced from 0.339 to 0.121, with an optimization range of 186.03%; the maximum temperature of the liquid-cooled plate after optimization was 24.7 ℃, with a temperature difference of 3 ℃, and the comprehensive error between simulation calculation results and experimental results was 3.79%.