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基于代谢组学和转录组学挖掘荷叶生物碱合成途径关键基因 |
李双琴(),汪仲毅,赵琬玥,陈龙清,胡慧贞() |
西南林业大学园林园艺学院/云南省功能性花卉资源及产业化技术工程研究中心,云南 昆明 650224 |
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Mining key genes of alkaloid synthesis pathway in lotus leaves based on metabolomics and transcriptomics |
Shuangqin LI(),Zhongyi WANG,Wanyue ZHAO,Longqing CHEN,Huizhen HU() |
College of Landscape Archi-tecture and Horticulture Sciences, Southwest Forestry University/Yunnan Engineering Research Center for Functional Flower Resources and Industrialization, Kunming 650224, Yunnan, China |
引用本文:
李双琴,汪仲毅,赵琬玥,陈龙清,胡慧贞. 基于代谢组学和转录组学挖掘荷叶生物碱合成途径关键基因[J]. 浙江大学学报(农业与生命科学版), 2023, 49(3): 328-340.
Shuangqin LI,Zhongyi WANG,Wanyue ZHAO,Longqing CHEN,Huizhen HU. Mining key genes of alkaloid synthesis pathway in lotus leaves based on metabolomics and transcriptomics. Journal of Zhejiang University (Agriculture and Life Sciences), 2023, 49(3): 328-340.
链接本文:
https://www.zjujournals.com/agr/CN/10.3785/j.issn.1008-9209.2022.04.291
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https://www.zjujournals.com/agr/CN/Y2023/V49/I3/328
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1 |
XUE J H, DONG W P, CHENG T, et al. Nelumbonaceae: systematic position and species diversification revealed by the complete chloroplast genome[J]. Journal of Systematics and Evolution, 2012, 50(6): 477-487. DOI: 10.1111/j.1759-6831.2012.00224.x
doi: 10.1111/j.1759-6831.2012.00224.x
|
2 |
黄博.中国荷叶资源及其生物活性研究[D].湖北,武汉:武汉大学,2011. HUANG B. Studies on the resources and bioactivities of lotus (Nelumbo nucifera) leaf in China[D]. Wuhan, Hubei: Wuhan University, 2011. (in Chinese with English abstract)
|
3 |
王冰洁.中国莲文化研究[D].陕西,杨凌:西北农林科技大学,2015. WANG B J. The research on Chinese lotus’ culture[D]. Yangling, Shaanxi: Northwest A&F University, 2015. (in Chinese with English abstract)
|
4 |
张行言,陈龙清.中国荷花新品种图志Ⅰ[M].北京:中国林业出版社,2011. ZHANG X Y, CHEN L Q. Atlas Ⅰ of New Lotus Cultivars in China[M]. Beijing: China Forestry Publishing House, 2011. (in Chinese)
|
5 |
MUKHERJEE P K, MUKHERJEE D, MAJI A K, et al. The sacred lotus (Nelumbo nucifera): phytochemical and therapeutic profile[J]. Journal of Pharmacy & Pharmacology, 2009, 61(4): 407-422. DOI: 10.1211/jpp/61.04.0001
doi: 10.1211/jpp/61.04.0001
|
6 |
朱玲平.荷叶生物碱代谢路径关键基因的挖掘[D].湖北,武汉:中国科学院大学,2015. ZHU L P. Identification of key genes involved in metabolic pathway of lotus leaf alkaloids[D]. Wuhan, Hubei: University of Chinese Academy of Sciences, 2015. (in Chinese with English abstract)
|
7 |
李梢.荷叶碱和荷叶提取物作为制备治疗萎缩性胃炎和/或阻断胃炎癌转化发生药物的应用:CN110393715A[P].2019-11-01. LI S. Application of lotus leaf alkaloid and lotus leaf extract as drugs for treating atrophic gastritis and/or blocking the transformation of gastritis cancer: CN110393715A[P]. 2019-11-01. (in Chinese)
|
8 |
孙常磊,朱丽平,段朝辉,等.荷叶碱或含其的植物提取物的应用:CN102949299B[P].2013-03-06. SUN C L, ZHU L P, DUAN C H, et al. Application of lotus leaf alkaloid or plant extract containing it: CN102949299B[P]. 2013-03-06. (in Chinese)
|
9 |
陈畅,谢永艳,黄丽萍.荷叶碱药理作用的研究进展[J].南京中医药大学学报,2021,37(4):619-624. DOI:10.14148/j.issn.1672-0482.2021.0619 CHEN C, XIE Y Y, HUANG L P. Advance of pharmaco-logical studies on nuciferine[J]. Journal of Nanjing University of Traditional Chinese Medicine, 2021, 37(4): 619-624. (in Chinese with English abstract)
doi: 10.14148/j.issn.1672-0482.2021.0619
|
10 |
赵力.莲叶片生物碱合成基因的挖掘及功能鉴定[D].福建,福州:福建农林大学,2019. ZHAO L. Mining and functional identification of alkaloid synthetic genes from lotus leaves[D]. Fuzhou, Fujian: Fujian Agriculture and Forestry University, 2019. (in Chinese with English abstract)
|
11 |
LOVE M I, HUBER W, ANDERS S. Moderated estimation of fold change and dispersion for RNA-Seq data with DESeq2[J]. Genome Biology, 2014, 15(12): 550. DOI: 10.1186/s13059-014-0550-8
doi: 10.1186/s13059-014-0550-8
|
12 |
VARET H, BRILLET-GUÉGUEN L, COPPÉE J Y, et al. SARTools: a DESeq2- and edgeR-based R pipeline for comprehensive differential analysis of RNA-Seq Data[J]. PLoS ONE, 2016, 11(6): e0157022. DOI: 10.1371/journal.pone.0157022
doi: 10.1371/journal.pone.0157022
|
13 |
THÉVENOT E A, ROUX A, XU Y, et al. Analysis of the human adult urinary metabolome variations with age, body mass index, and gender by implementing a comprehensive workflow for univariate and OPLS statistical analyses[J]. Journal of Proteome Research, 2015, 14(8): 3322-3335. DOI: 10.1021/acs.jproteome.5b00354
doi: 10.1021/acs.jproteome.5b00354
|
14 |
PATRA B, SCHLUTTENHOFER C, WU Y M, et al. Transcriptional regulation of secondary metabolite biosynthesis in plants[J]. Biochimica et Biophysica Acta, 2013, 1829(11): 1236-1247. DOI: 10.1016/j.bbagrm.2013.09.006
doi: 10.1016/j.bbagrm.2013.09.006
|
15 |
ZHOU M L, MEMELINK J. Jasmonate-responsive trans-cription factors regulating plant secondary metabolism[J]. Biotechnology Advances, 2016, 34(4): 441-449. DOI: 10.1016/j.biotechadv.2016.02.004
doi: 10.1016/j.biotechadv.2016.02.004
|
16 |
DENG X B, ZHU L P, FAN T, et al. Analysis of isoquinoline alkaloid composition and wound-induced variation in Nelumbo using HPLC-MS/MS[J]. Journal of Agricultural and Food Chemistry, 2016, 64(5): 1130-1136. DOI: 10.1021/acs.jafc.5b06099
doi: 10.1021/acs.jafc.5b06099
|
17 |
BOKE H, OZHUNER E, TURKTAS M, et al. Regulation of the alkaloid biosynthesis by miRNA in opium poppy[J]. Plant Biotechnology Journal, 2015, 13(3): 409-420. DOI: 10.1111/pbi.12346
doi: 10.1111/pbi.12346
|
18 |
WINZER T, KERN M, KING A J, et al. Morphinan biosynthesis in opium poppy requires a P450-oxidoreductase fusion protein[J]. Science, 2015, 349(6245): 309-312. DOI: 10.1126/science.aab1852
doi: 10.1126/science.aab1852
|
19 |
OTANI M, SHITAN N, SAKAI K, et al. Characterization of vacuolar transport of the endogenous alkaloid berberine in Coptis japonica [J]. Plant Physiology, 2005, 138(4): 1939-1946. DOI: 10.1104/pp.105.064352
doi: 10.1104/pp.105.064352
|
20 |
YAMADA Y, MOTOMURA Y, SATO F. CjbHLH1 homologs regulate sanguinarine biosynthesis in Eschscholzia californica cells[J]. Plant and Cell Physiology, 2015, 56(5): 1019-1030. DOI: 10.1093/pcp/pcv027
doi: 10.1093/pcp/pcv027
|
21 |
TORRES M A, HOFFARTH E, EUGENIO L, et al. Structural and functional studies of pavine N-methyltransferase from Thalictrum flavum reveal novel insights into substrate recognition and catalytic mechanism[J]. Journal of Biological Chemistry, 2016, 291(45): 23403-23415. DOI: 10.1074/jbc.M116.747261
doi: 10.1074/jbc.M116.747261
|
22 |
DU H, YOU J S, ZHAO X, et al. Antiobesity and hypolipi-demic effects of lotus leaf hot water extract with taurine in rats fed a high fat diet[J]. Journal of Biomedical Science, 2010, 17(Suppl. 1): S42. DOI: 10.1186/1423-0127-17-S1-S42
doi: 10.1186/1423-0127-17-S1-S42
|
23 |
范婷婷,法鲁克,方芳,等.荷叶总生物碱降脂减肥作用的体内外试验[J].浙江大学学报(农业与生命科学版),2013,39(2):141-148. DOI:10.3785/j.issn.1088-9209.2012.11.064 FAN T T, FA L K, FANG F, et al. Effect of total alkaloids from lotus leaves on body mass and lipid regulation in vivo and in vitro [J]. Journal of Zhejiang University (Agriculture and Life Sciences), 2013, 39(2): 141-148. (in Chinese with English abstract)
doi: 10.3785/j.issn.1088-9209.2012.11.064
|
24 |
JUNG M A, LEE S Y, HAN S H, et al. Hypocholesterolemic effects of Curcuma longa L. with Nelumbo nucifera leaf in an in vitro model and a high cholesterol diet-induced hyper-cholesterolemic mouse mode[J]. Animal Cells Systems, 2015, 19(2): 133-143. DOI: 10.1080/19768354.2014.992953
doi: 10.1080/19768354.2014.992953
|
25 |
PAULI H H, KUTCHAN T M. Molecular cloning and functional heterologous expression of two alleles encoding (S)-N-methylcoclaurine 3 ´ -hydroxylase (CYP80B1), a new methyl jasmonate-inducible cytochrome P-450-dependent mono-oxygenase of benzylisoquinoline alkaloid biosynthesis[J]. The Plant Journal, 1998, 13(6): 793-801.
|
26 |
GURKOK T, OZHUNER E, PARMAKSIZ I, et al. Functional characterization of 4 ´ OMT and 7OMT genes in BIA biosyn-thesis[J]. Frontiers in Plant Science, 2016, 7: 98. DOI: 10.3389/fpls.2016.00098
doi: 10.3389/fpls.2016.00098
|
27 |
YANG M, ZHU L P, LI L, et al. Digital gene expression analysis provides insight into the transcript profile of the genes involved in aporphine alkaloid biosynthesis in lotus (Nelumbo nucifera)[J]. Frontiers in Plant Science, 2017, 8: 80. DOI: 10.3389/fpls.2017.00080
doi: 10.3389/fpls.2017.00080
|
28 |
VIMOLMANGKANG S, DENG X B, OWITI A, et al. Evolutionary origin of the NCSI gene subfamily encoding norcoclaurine synthase is associated with the biosynthesis of benzylisoquinoline alkaloids in plants[J]. Scientific Reports, 2016, 6: 26323. DOI: 10.1038/srep26323
doi: 10.1038/srep26323
|
29 |
DENG X B, ZHAO L, FANG T, et al. Investigation of benzylisoquinoline alkaloid biosynthetic pathway and its transcriptional regulation in lotus[J]. Horticulture Research, 2018, 5: 29. DOI: 10.1038/s41438-018-0035-0
doi: 10.1038/s41438-018-0035-0
|
30 |
SHOJI T, KAJIKAWA M, HASHIMOT T. Clustered trans-cription factor genes regulate nicotine biosynthesis in tobacco[J]. The Plant Cell, 2010, 22(10): 3390-3409. DOI: 10.1105/tpc.110.078543
doi: 10.1105/tpc.110.078543
|
31 |
VAN MOERKERCKE A, STEENSMA P, GARIBOLDI I, et al. The basic helix-loop-helix transcription factor BIS2 is essential for monoterpenoid indole alkaloid production in the medicinal plant Catharanthus roseus [J]. The Plant Journal, 2016, 88(1): 3-12. DOI: 10.1111/tpj.13230
doi: 10.1111/tpj.13230
|
32 |
KATO N, DUBOUZET E, KOKABU Y, et al. Identification of a WRKY protein as a transcriptional regulator of benzy-lisoquinoline alkaloid biosynthesis in Coptis japonica [J]. Plant and Cell Physiology, 2007, 48(1): 8-18. DOI: 10.1093/pcp/pcl041
doi: 10.1093/pcp/pcl041
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