The blasting vibration speed and dynamic strain distribution characteristics of the pipeline under no pressure and different working conditions (different doses and different blasting distances) were analyzed through a full-scale embedded high-density polyethylene (HDPE) pipeline field blasting test, combined with the characteristics of the strata in the pipeline pre-burial site in Wuhan. The reliability of the calculation model and the parameters was verified by comparing with the field test data, combined with LSDYNA dynamic finite element analysis method. The dynamic response characteristics of HDPE pipelines with different operating conditions (different filling water level heights) under blasting vibration loads were analyzed. A safety control standard for the HDPE corrugated pipe blasting vibration speed was proposed, combined with the hoop allowable stress control criteria for pipeline operating conditions. Results indicate that the circumferential strain reaches the largest value when the HDPE pipeline is affected by blasting vibration. The combined vibration and the equivalent stress of the pipeline decrease with the increase of the water level in the pipe, and the combined vibration speed and the equivalent stress of the front explosion side of the pipeline are greater than those of the back explosion side at the same section. The maximum combined vibration of an empty pipe was 18.56 cm/s, and the equivalent stress was 0.912 MPa. The vibration speed and the main frequency of the X-direction at the dangerous section of the pipeline decrease as the water level rises, and these of the Y and Z directions increase as the water level rises. The safety control speed of the pipeline operating state obtained through the preparation of Mises yield strength was 25.79 cm/s.