新型经颅磁刺激三层-8字形线圈的结构设计

doi:10.3785/j.issn.1008-973X.2021.04.022

浙江大学学报(工学版)

2021, Vol. 55

Issue (4): 793-800 DOI: 10.3785/j.issn.1008-973X.2021.04.022

电气工程

新型经颅磁刺激三层-8字形线圈的结构设计

熊慧(

),景昭,刘近贞

1. 天津工业大学电气工程及自动化学院，天津 300387
2. 天津工业大学电工电能新技术天津市重点实验室，天津 300387

Structural design of novel three-layer figure-of-8 coil for transcranial magnetic stimulation

Hui XIONG(

),Zhao JING,Jin-zhen LIU

1. School of Electrical Engineering and Automation, TIANGONG University, Tianjin 300387, China
2. Tianjin Key Laboratory of Advanced Technology of Electrical Engineering and Energy, TIANGONG University, Tianjin 300387, China

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摘要：

基于磁场的叠加与抵消，设计与优化具有特殊结构和电流方向的三层-8字形线圈. 利用COMSOL仿真软件，分析三层-8字形线圈尺寸和沿切线旋转角度的改变对刺激性能的影响，优化线圈结构. 与8字形线圈相比，优化后的三层-8字形线圈的刺激强度提高33.92%，聚焦性提高25.43%. 结果表明，在目标靶点处，优化后三层-8字形线圈具有更强的刺激强度和聚焦性，有效减弱对非目标区域的不良影响，保证TMS治疗的安全性. 通过刺激真实头部模型，验证优化后三层-8字形线圈的性能优势.

关键词： 经颅磁刺激; 三层-8字形线圈; 聚焦性; 刺激深度; 刺激强度

Abstract:

A new three-layer figure-of-8 coil with the special structure and current direction was designed and optimized based on the superposition and cancellation of magnetic field. COMSOL simulation software was used to analyze the effects of the three-layer figure-of-8 coil with the changing of size and the rotation angle along the tangent line on the stimulation performance, and the coil structure was optimized. The stimulation intensity of the optimized three-layer figure-of-8 coil was increased by 33.92% and the focality was improved by 25.43% compared with figure-of-8 coil. Results show that the three-layer figure-of-8 coil has better stimulation intensity and focality at a certain target position. Then the adverse effects of non-target areas were greatly reduced, and the safety of TMS treatment was guaranteed. The performance advantages of the optimized three-layer-8-shaped coil were verified by stimulating the realistic head model.

Key words: transcranial magnetic stimulation three-layer figure-of-8 coil focality stimulation depth stimulation intensity

收稿日期: 2020-04-01 出版日期: 2021-05-07

CLC:

R 318

基金资助: 国家自然科学基金资助项目（61871288）；天津市高等学校创新团队培养计划资助项目（TD13-5036）；天津市自然科学基金资助项目（18JCYBJC 90400，18JCQNJC84000）

作者简介: 熊慧（1978—），女，副教授，从事生物医学电磁学的研究. orcid.org/0000-0001-8940-5626. E-mail： xionghui@tiangong.edu.cn

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引用本文:

熊慧,景昭,刘近贞. 新型经颅磁刺激三层-8字形线圈的结构设计[J]. 浙江大学学报(工学版), 2021, 55(4): 793-800.

Hui XIONG,Zhao JING,Jin-zhen LIU. Structural design of novel three-layer figure-of-8 coil for transcranial magnetic stimulation. Journal of ZheJiang University (Engineering Science), 2021, 55(4): 793-800.

链接本文:

http://www.zjujournals.com/eng/CN/10.3785/j.issn.1008-973X.2021.04.022 或 http://www.zjujournals.com/eng/CN/Y2021/V55/I4/793

图 1 2层球头模型和刺激线圈

图 2 具有特殊电流方向和半径尺寸的三层-8字形线圈以及沿切线旋转的三类结构

表 1 改变外侧单元线圈外半径得到的7类线圈

表 2 3类不同线圈的仿真计算结果

图 3 最大感应电场强度与旋转角度θ、半径的关系

图 4 刺激深度与旋转角度θ、半径的关系

图 5 聚焦面积与旋转角度θ、半径的关系

图 6 优化后的三层-8字形线圈在大脑皮质层表面的感应电场强度分布

表 3 8字形线圈与优化前后三层-8字形线圈的仿真计算结果

图 7 真实头部模型

图 8 基于真实头部模型，3类线圈的感应电场强度分布图

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