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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2005, Vol. 6 Issue ( 6): 11-    DOI: 10.1631/jzus.2005.B0508
    
Optimization of angiotensin I-converting enzyme (ACE) inhibition by rice dregs hydrolysates using response surface methodology
HE Guo-qing, XUAN Guo-dong, RUAN Hui, CHEN Qi-he, XU Ying
Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310029, China
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Abstract  Angiotensin I-converting enzyme (ACE) inhibitory peptides have been shown to have antihypertensive effects and have been utilized for physiologically functional foods and pharmaceuticals. The ACE inhibitory ability of a hydrolysate is determined by its peptide composition. However, the peptide composition of a hydrolysate depends on proteolytic enzyme and the hydrolysis conditions. In this study, the effect of process conditions on the ACE inhibitory activity of rice dregs hydrolyzed with a trypsin was investigated systematically using response surface methodology. It was shown that the ACE inhibitory activity of rice dregs hydrolysates could be controlled by regulation of five process conditions. Hydrolysis conditions for optimal ACE inhibition were defined using the response surface model of fractional factorial design (FFD), steepest ascent design, and central composite design (CCD).

Key words： Food Science and Nutrition Angiotensin I-converting enzyme inhibitor      Rice dregs      Response surface methodology     
Received: 03 December 2004     
CLC:  TS201.1  
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HE Guo-qing
XUAN Guo-dong
RUAN Hui
CHEN Qi-he
XU Ying
Cite this article:

HE Guo-qing, XUAN Guo-dong, RUAN Hui, CHEN Qi-he, XU Ying. Optimization of angiotensin I-converting enzyme (ACE) inhibition by rice dregs hydrolysates using response surface methodology. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2005, 6( 6): 11-.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.2005.B0508     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2005/V6/I 6/11

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