生物3D打印——从形似到神似

doi:10.3785/j.issn.1008-973X.2019.03.001

浙江大学学报(工学版)

2019, Vol. 53

Issue (3): 407-419 DOI: 10.3785/j.issn.1008-973X.2019.03.001

机械工程

生物3D打印——从形似到神似

贺永(

),高庆,刘安,孙苗,傅建中

浙江大学流体动力与机电系统国家重点实验室机械工程学院，浙江杭州 310027

3D bioprinting: from structure to function

Yong HE(

),Qing GAO,An LIU,Miao SUN,Jian-zhong FU

State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou 310027, China

全文: PDF(1365 KB) HTML

摘要：

系统回顾生物3D打印的提出背景，给出生物3D打印的研究范围，梳理生物3D打印的发展历程. 重点聚焦于回顾操纵细胞的生物3D打印研究，并结合课题组近年来的研究及思考，对生物3D打印的发展进行展望. 更好地结合临床需求，实现从组织结构的仿生制造过渡到功能化的再造是生物3D打印未来取得突破的关键.

关键词： 生物3D打印; 细胞打印; 生物墨水; 生物打印机; 组织工程; 仿生制造

Abstract:

Review the background of 3D bioprinting systematically, provide the research scope of 3D bioprinting, and summarize the development of 3D bioprinting. This review focuses on the 3D bioprinting of manipulating cells, and the development of 3D bioprinting was prospected combined with the research and thought of our research group in recent years. To better integrate clinical needs to realize transition from bionic manufacturing of organizational structure to functional reconstruction is the key to the breakthrough of 3D bioprinting in the future.

Key words: 3D bioprinting cell printing bioink bioprinter tissue engineering bionic manufacturing

收稿日期: 2018-06-19 出版日期: 2019-03-04

CLC:

R 318.08

作者简介: 贺永（1979—），男，教授，从事生物制造研究. orcid.org/0000-0002-9099-0831. E-mail： yongqin@zju.edu.cn

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引用本文:

贺永,高庆,刘安,孙苗,傅建中. 生物3D打印——从形似到神似[J]. 浙江大学学报(工学版), 2019, 53(3): 407-419.

Yong HE,Qing GAO,An LIU,Miao SUN,Jian-zhong FU. 3D bioprinting: from structure to function. Journal of ZheJiang University (Engineering Science), 2019, 53(3): 407-419.

链接本文:

http://www.zjujournals.com/eng/CN/10.3785/j.issn.1008-973X.2019.03.001 或 http://www.zjujournals.com/eng/CN/Y2019/V53/I3/407

图 1 生物3D打印原理

图 2 喷墨式生物3D打印原理

图 3 激光直写式生物3D打印原理

图 4 挤出式生物3D打印原理

图 5 基于数字微镜（DMD）的光固化式生物3D打印原理

图 6 典型的基于挤出方式的生物3D打印机组成

图 7 商业化的生物3D打印机

图 8 课题组研发的EFL-BP系列生物3D打印机

图 9 课题组设计的原创打印工艺

图 10 软骨组织的生物3D打印

图 11 皮肤的生物打印

图 12 血管的生物3D打印

图 13 肿瘤模型的生物3D打印

图 14 复杂组织器官的3D打印

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