With the development and evolution of consumer culture, product meaning becomes a more and more important factor for consumers to choose what to buy in similar products. In view of the existing research for opportunity identification confined to user needs or technology development or both of the two factors, combined with the designer's guiding effect for product design innovation, the process of product design innovation front end opportunity identification was established, which was based on three factors like the product meaning, technology development and customer needs. The process of opportunity identification was as follows, the first step was to divide the user group by some standards, and then studying the user group needs respectively, choosing the key product technologies and analyzing their status, and analyzing product meaning influencing factors, according to the factors metioned above to identify the target user group and the product design objective for the group, the second step was to classify and arrange the target group needs, the key product technologies' status and product meaning expressions as the clues of product design innovation opportunity, the third step was to transform the opportunity clues which were classified and arranged in the previous step into innovation opportunities by using a variety of innovative tools and innovative thinking integration, and at last according to the constrains of the innovation opportunities which were obtained by the group needs, the key product technologies' status and product meaning clues, incorporating with the corporate philosophy, fund allocation and transfer and other factors, to choose couple of opportunities to be the opportunity program, which might be more suitable for the enterprise development. Finally, the opportunity identification for product design innovation front end process is verified by the example of the nail gun. The process has achieved the design-driven, the market-driven and technology-driven opportunity recognition, and it meets customer demand, adapts to the technology development and expresses the meaning of product at the same time, which provides solution for evolutionary and upgrade of products.