A design strategy through appropriately opening the passing space interface in response to climate was proposed as a solution to high energy consumption and formal convergence within the high-speed railway station buildings. Performance simulation tools based on building information modeling (BIM) were used to build a typical model, and the opening time period for different climate zones were determined according to wind and thermal environment simulation analysis. Results show that it is feasible to open up the passing space interface, meeting the requirement of indoor thermal comfort, in the case of a typical summer calculation day in climate zones except in hot summer and warm winter zone (Guangzhou as an example). Meanwhile, during the particular time periods of a year, interface opening is beneficial to energy savings and emission reduction in station buildings, especially in hot summer and cold winter zone (Shanghai as an example) and cold zone (Beijing as an example). The energy-savings reached up to 44.8% and 32.2%, respectively, as well as carbon reduction rates of 36.1% and 21.3%. Hence, the proposed strategy has significant application potential in the green design schemes of high-speed railway station buildings and can explore ideas for regional expression of spatial forms.