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浙江大学学报(工学版)
浙江大学学报(工学版)
生物医学工程     
呼吸引起的肝脏运动模式分析
杨明雷1,丁辉1,王晓东2,王广志1
1. 清华大学 生物医学工程学系,北京 100084;2. 北京大学肿瘤医院暨北京市肿瘤防治研究所介入科,恶性肿瘤发病机制及转化研究教育部重点实验室,北京 100142
Analysis of respiration-induced liver motion mode
YANG Ming-lei1, DING Hui1, WANG Xiao-dong2, WANG Guang-zhi1
1. Department of Biomedical Engineering, Tsinghua University, Beijing 100084, China; 2. Department of Interventional Therapy, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education),  Peking University Cancer Hospital and Institute, Beijing 100142, China
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摘要：

为补偿肝脏运动,分析呼吸引起的肝脏空间运动和形变,并尝试将其简化为刚性运动模型进行补偿.利用基于表面和基于互信息的3D-3D图像刚性配准方法分析4例肝脏空间运动的规律并进行补偿,比较使用手工分割肝脏轮廓和肝脏灰度信息进行配准的结果及其补偿效果,评估2种思路的可靠性,并进一步评价刚体运动模型简化的可行性.结果表明：刚性运动模型、简化的平移运动模型和矢状面2D运动模型在实际应用中具有可行性,此3种模型都可以补偿80％以上的呼吸影响；使用肝脏灰度信息比手工分割轮廓建模和补偿的结果更可靠.上述结论对在超声融合多模成像中快速建模和实时补偿呼吸对肝脏运动的影响有一定的参考价值.
Abstract:

The respiration-induced liver motion and deformation was analyzed, and a rigid motion model was utilized to simplify the liver motion and compensate for it. 3D-3D image rigid registration was applied to obtain the motion parameters of four livers using surface and mutual information as the cost function respectively. Then the liver motion patterns were analyzed and the motion was compensated based on these parameters. Afterwards, the registration results and compensation performance, as well as their reliability were compared between manual segmented liver contour group and liver gray scale information group．Furthermore, the feasibility of the rigid model’s further simplification was evaluated. The result shows that the rigid model and the further simplified translation motion model, even the 2D sagittal in-plane translation motion model are feasible. Over 80% of respiratory affection can be avoided using the simplified motion models. The modeling and compensation of liver motion using liver gray scale information is more credible than those using manual segmented liver contour. The above conclusion is valuable for real-timely compensating for respiration-induced liver motion in ultrasound fusion multimodal imaging in engineering.
出版日期: 2014-09-01
:  R 318  
基金资助:

国家自然科学基金资助项目（81271671,81271735）
通讯作者: 王广志,男,教授,博导     E-mail: wgz-dea@tsinghua.edu.cn
作者简介: 杨明雷(1988-), 男,硕士生, 从事超声图像融合科研工作. E-mail: luoluoqingchen@163.com
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杨明雷,丁辉,王晓东,王广志. 呼吸引起的肝脏运动模式分析[J]. 浙江大学学报(工学版), 10.3785/j.issn.1008-973X.2014.09.024.

YANG Ming-lei, DING Hui, WANG Xiao-dong, WANG Guang-zhi. Analysis of respiration-induced liver motion mode. JOURNAL OF ZHEJIANG UNIVERSITY (ENGINEERING SCIENCE), 10.3785/j.issn.1008-973X.2014.09.024.

链接本文:

http://www.zjujournals.com/eng/CN/10.3785/j.issn.1008-973X.2014.09.024    或    http://www.zjujournals.com/eng/CN/Y2014/V48/I9/1710

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