| Biomedicine |
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| Study progress on mechanism of severe acute pancreatitis complicated with hepatic injury |
| ZHANG Xi-ping, WANG Lei, ZHANG Jie |
| Department of General Surgery, Hangzhou First People’s Hospital, Hangzhou 310006, China; Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, China |
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Abstract Study on the action mechanism of inflammatory mediators generated by the severe acute pancreatitis (SAP) in multiple organ injury is a hotspot in the surgical field. In clinical practice, the main complicated organ dysfunctions are shock, respiratory failure, renal failure, encephalopathy, with the rate of hepatic diseases being closely next to them. The hepatic injury caused by SAP cannot only aggravate the state of pancreatitis, but also develop into hepatic failure and cause patient death. Its complicated pathogenic mechanism is an obstacle in clinical treatment. Among many pathogenic factors, the changes of vasoactive substances, participation of inflammatory mediators as well as OFR (oxygen free radical), endotoxin, etc. may play important roles in its progression.
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Received: 13 June 2006
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