Please wait a minute...
ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2005, Vol. 6 Issue (9): 919-925    DOI: 10.1631/jzus.2005.B0919
Biomedicine     
In vitro study of immunosuppressive effect of apoptotic cells
ZHANG Wen-jin, ZHENG Shu-sen
Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310027, China
Download:     PDF (0 KB)     
Export: BibTeX | EndNote (RIS)      

Abstract  Recent studies revealed that apoptotic cells are actively involved in immunosuppression and anti-inflammation. After being phagocytosed by macrophages, apoptotic cells can actively regulate cytokines secretion from lipopolysaccharide (LPS)-stimulated macrophages, in which the secretion of immunosuppressive cytokines such as interleukin-10 (IL-10) is increased while the pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNFα), interleukin-1beta (IL-1β) and leukin-8 (IL-8) are suppressed. In this paper, we first present evidence that phagocytosed apoptotic cells regulate cytokine secretion of LPS-stimulated macrophages, but also inhibit the activation of T lymphocytes stimulated by ConA. These data suggest that apoptotic cells can alter the biological behavior of macrophages which gain immunosuppressive property.

Key words： Macrophages      Apoptosis      Cytokines      Immunosuppression     
Received: 09 August 2004     
CLC:  R392  
Service
E-mail this article
Add to my bookshelf
Add to citation manager
E-mail Alert
RSS
Articles by authors
ZHANG Wen-jin
ZHENG Shu-sen
Cite this article:

ZHANG Wen-jin, ZHENG Shu-sen. In vitro study of immunosuppressive effect of apoptotic cells. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2005, 6(9): 919-925.

URL:

http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.2005.B0919     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2005/V6/I9/919

[1] Ying-shan Zhou, Yuan-xing Gu, Bao-zhu Qi, Yi-kai Zhang, Xiao-liang Li, Wei-huan Fang. Porcine circovirus type 2 capsid protein induces unfolded protein response with subsequent activation of apoptosis[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2017, 18(4): 316-323.
[2] Run-ting Huang, Qing Huang, Gen-liang Wu, Chun-guang Chen, Zong-jun Li. Evaluation of the antioxidant property and effects in Caenorhabditis elegans of Xiangxi flavor vinegar, a Hunan local traditional vinegar[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2017, 18(4): 324-333.
[3] Shu-min Liu, Shi-yi Ou, Hui-hua Huang. Green tea polyphenols induce cell death in breast cancer MCF-7 cells through induction of cell cycle arrest and mitochondrial-mediated apoptosis[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2017, 18(2): 89-98.
[4] Bo Wang, Sheng-yun Lin, Ying-ying Shen, Li-qiang Wu, Zhen-zhen Chen, Jing Li, Zhi Chen, Wen-bin Qian, Jian-ping Jiang. Pure total flavonoids from Citrus paradisi Macfadyen act synergistically with arsenic trioxide in inducing apoptosis of Kasumi-1 leukemia cells in vitro[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2015, 16(7): 580-585.
[5] Chun-qi Gao, Yin-ling Zhao, Hai-chang Li, Wei-guo Sui, Hui-chao Yan, Xiu-qi Wang. Heat stress inhibits proliferation, promotes growth, and induces apoptosis in cultured Lantang swine skeletal muscle satellite cells[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2015, 16(6): 549-559.
[6] Hai-tao Yu, Juan Zhen, Bo Pang, Jin-ning Gu, Sui-sheng Wu. Ginsenoside Rg1 ameliorates oxidative stress and myocardial apoptosis in streptozotocin-induced diabetic rats[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2015, 16(5): 344-354.
[7] Danuta Ro??, Przemys?aw Adamczyk, Joanna Boinska, Robert Szafkowski, Irena Ponikowska, Katarzyna Stankowska, Barbara Góralczyk, Barbara Ruszkowska-Ciastek. CRP, but not TNF-α or IL-6, decreases after weight loss in patients with morbid obesity exposed to intensive weight reduction and balneological treatment[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2015, 16(5): 404-411.
[8] Hai-sheng Xu, Sun-jian Lyu, Jie-hao Xu, Bin-jie Lu, Jing Zhao, Song Li, Yi-qun Li, Yu-yin Chen. Effect of lipopolysaccharide on the hemocyte apoptosis of Eriocheir sinensis[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2015, 16(12): 971-979.
[9] Hua-li Li, Zong-jun Li, Zhong-shan Wei, Ting Liu, Xiao-zuo Zou, Yong Liao, Yu Luo. Long-term effects of oral tea polyphenols and Lactobacillus brevis M8 on biochemical parameters, digestive enzymes, and cytokines expression in broilers[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2015, 16(12): 1019-1026.
[10] Lei Tian, Xiao-qian Dang, Chun-sheng Wang, Pei Yang, Chen Zhang, Kun-zheng Wang. Effects of sodium ferulate on preventing steroid-induced femoral head osteonecrosis in rabbits[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2013, 14(5): 426-437.
[11] Qin Fu, Chen He, Zheng-rong Mao. Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2013, 14(1): 8-24.
[12] Yin-he Feng, Hui Mao. Expression and preliminary functional analysis of Siglec-F on mouse macrophages[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2012, 13(5): 386-394.
[13] Tong-liang Bu, Yu-dong Jia, Jin-xing Lin, Yu-ling Mi, Cai-qiao Zhang. Alleviative effect of quercetin on germ cells intoxicated by 3-methyl-4-nitrophenol from diesel exhaust particles[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2012, 13(4): 318-326.
[14] Shailendra Kapoor. Artesunate and its emerging anti-neoplastic effects: beyond its role in attenuating tumor growth in osteosarcomas[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2012, 13(12): 1029-1030.
[15] Yao-wen Wang, Ji-hao Ren, Kun Xia, Shu-hui Wang, Tuan-fang Yin, Ding-hua Xie, Li-hua Li. Effect of mitomycin on normal dermal fibroblast and HaCat cell: an in vitro study[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2012, 13(12): 997-1005.