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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2015, Vol. 16 Issue (12): 1019-1026    DOI: 10.1631/jzus.B1500160
Articles     
Long-term effects of oral tea polyphenols and Lactobacillus brevis M8 on biochemical parameters, digestive enzymes, and cytokines expression in broilers
Hua-li Li, Zong-jun Li, Zhong-shan Wei, Ting Liu, Xiao-zuo Zou, Yong Liao, Yu Luo
Hunan Provincial Key Laboratory of Food Science and Biotechnology, College of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China; National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, Changsha 410128, China; Hunan Institute of Animal and Veterinary Science, Changsha 410131, China
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Abstract  This study investigates the long-term effects of oral tea polyphenols (TPs) and Lactobacillus brevis M8 (LB) on biochemical parameters, digestive enzymes, and cytokines expression in broilers. In experiment 1, 240 broiler chickens were selected to investigate the effects of 0.06 g/kg body weight (BW) TP and 1.0 ml/kg BW LB on broilers; in experiment 2, 180 broiler chickens were assigned randomly to three groups to investigate the effects of different dosages of TP (0.03, 0.06, and 0.09 g/kg BW) combined with 1.0 ml/kg BW LB on broilers; in experiment 3, 180 broiler chickens were assigned randomly to three groups to investigate the effects of different dosages of LB (0.5, 1.0, and 1.5 ml/kg BW) combined with 0.06 g/kg BW TP on broilers. The results showed that TP and LB affected serum biochemical parameters, and TP reduced serum cholesterol (CHO) and low-density lipoprotein cholesterol (LDL-C) abundances in a dosage-dependent manner (P<0.05) on Day 84. Meanwhile, broilers fed a diet supplemented with TP or LB had a lower intestinal lipase activity on Day 84 compared with the control group (P<0.05). Middle and high dosages of TP increased pancreatic lipase and proventriculus pepsin activities (P<0.05). Also middle and high dosages of LB significantly enhanced pancreatic lipase activity (P<0.05), while high LB supplementation inhibited intestinal trypsase (P<0.05) on Day 84. Furthermore, both TP and LB reduced intestinal cytokine expression and nuclear factor-κ B (NF-κB) mRNA level on Days 56 and 84. In conclusion, long-term treatment of TP and LB improved lipid metabolism and digestive enzymes activities, and affected intestinal inflammatory status, which may be associated with the NF-κB signal.

Key words： Tea polyphenols      Lactobacillus brevis      Cytokines      Broilers     
Received: 28 June 2015      Published: 04 December 2015
CLC:  S831.5  
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Hua-li Li
Zong-jun Li
Zhong-shan Wei
Ting Liu
Xiao-zuo Zou
Yong Liao
Yu Luo
Cite this article:

Hua-li Li, Zong-jun Li, Zhong-shan Wei, Ting Liu, Xiao-zuo Zou, Yong Liao, Yu Luo. Long-term effects of oral tea polyphenols and Lactobacillus brevis M8 on biochemical parameters, digestive enzymes, and cytokines expression in broilers. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2015, 16(12): 1019-1026.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1500160     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2015/V16/I12/1019

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