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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2015, Vol. 16 Issue (5): 344-354    DOI: 10.1631/jzus.B1400204
Articles     
Ginsenoside Rg1 ameliorates oxidative stress and myocardial apoptosis in streptozotocin-induced diabetic rats
Hai-tao Yu, Juan Zhen, Bo Pang, Jin-ning Gu, Sui-sheng Wu
Department of Cardiovascular Medicine, the First Hospital of Jilin University, Changchun 130021, China; Department of Cardiovascular Medicine, PLA No. 208 Hospital, Changchun 130062, China; Department of Cardiovascular Medicine, the Second Hospital of Jilin University, Changchun 130041, China
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Abstract  We evaluated the cardioprotective effects of ginsenoside Rg1 in a diabetic rat model induced with high-fat diet and intraperitoneal injection of streptozotocin. Ginsenoside Rg1 was injected intraperitoneally for 12 weeks. Myocardial injury indices and oxidative stress markers were determined. Changes in cardiac ultrastructure were evaluated with transmission electron microscopy. Myocardial apoptosis was assessed via terminal deoxynucleotidyl transferase (TDT)-mediated DNA nick-end labeling (TUNEL) and immunohistochemistry. Ginsenoside Rg1 was associated with a significant dose-dependent reduction in serum levels of creatinine kinase MB and cardiac troponin I, and lessened ultrastructural disorders in diabetic myocardium, relative to the untreated diabetic model rats. Also, compared with the untreated diabetic rats, significant reductions in serum and myocardial levels of malondialdehyde were noted in the ginsenoside Rg1-treated groups, and increased levels of the antioxidants (superoxide dismutase, catalase, and glutathione peroxidase) were detected. TUNEL staining indicated reduced myocardial apoptosis in ginsenoside Rg1-treated rats, which may be associated with reduced levels of caspase-3 (CASP3) and increased levels of B-cell lymphoma-extra-large (Bcl-xL) in the diabetic myocardium. Ginsenoside Rg1 treatment of diabetic rats was associated with reduced oxidative stress and attenuated myocardial apoptosis, suggesting that ginsenoside Rg1 may be of potential preventative and therapeutic value for cardiovascular injury in diabetic patients.

Key words： Ginsenoside Rg1      Diabetic cardiomyopathy      Oxidative stress      Apoptosis      Caspase-3 (CASP3)     
Received: 21 July 2014      Published: 04 May 2015
CLC:  R542.2  
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Hai-tao Yu
Juan Zhen
Bo Pang
Jin-ning Gu
Sui-sheng Wu
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Hai-tao Yu, Juan Zhen, Bo Pang, Jin-ning Gu, Sui-sheng Wu. Ginsenoside Rg1 ameliorates oxidative stress and myocardial apoptosis in streptozotocin-induced diabetic rats. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2015, 16(5): 344-354.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1400204     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2015/V16/I5/344

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