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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2014, Vol. 15 Issue (6): 540-547    DOI: 10.1631/jzus.B1300250
Articles     
Ferulic acid prevents liver injury and increases the anti-tumor effect of diosbulbin B in vivo
Jun-ming Wang, Yu-chen Sheng, Li-li Ji, Zheng-tao Wang
MOE Key Laboratory for Standardization of Chinese Medicines and Shanghai Key Laboratory of Complex Prescription, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Center for Drug Safety Evaluation and Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450008, China
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Abstract  The present study is designed to investigate the protection by ferulic acid against the hepatotoxicity induced by diosbulbin B and its possible mechanism, and further observe whether ferulic acid augments diosbulbin B-induced anti-tumor activity. The results show that ferulic acid decreases diosbulbin B-increased serum alanine transaminase/aspartate transaminase (ALT/AST) levels. Ferulic acid also decreases lipid peroxide (LPO) levels which are elevated in diosbulbin B-treated mice. Histological evaluation of the liver demonstrates hydropic degeneration in diosbulbin B-treated mice, while ferulic acid reverses this injury. Moreover, the activities of copper- and zinc-containing superoxide dismutase (CuZn-SOD) and catalase (CAT) are decreased in the livers of diosbulbin B-treated mice, while ferulic acid reverses these decreases. Further results demonstrate that the mRNA expressions of CuZn-SOD and CAT in diosbulbin B-treated mouse liver are significantly decreased, while ferulic acid prevents this decrease. In addition, ferulic acid also augments diosbulbin B-induced tumor growth inhibition compared with diosbulbin B alone. Taken together, the present study shows that ferulic acid prevents diosbulbin B-induced liver injury via ameliorating diosbulbin B-induced liver oxidative stress injury and augments diosbulbin B-induced anti-tumor activity.

Key words： Ferulic acid      Diosbulbin B      Hepatotoxicity      Oxidative stress injury      Anti-tumor activity     
Received: 16 September 2013      Published: 07 June 2014
CLC:  R932  
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Jun-ming Wang
Zheng-tao Wang
Yu-chen Sheng
Li-li Ji
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Jun-ming Wang, Yu-chen Sheng, Li-li Ji, Zheng-tao Wang. Ferulic acid prevents liver injury and increases the anti-tumor effect of diosbulbin B in vivo. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2014, 15(6): 540-547.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1300250     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2014/V15/I6/540

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