Please wait a minute...
ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2009, Vol. 10 Issue (3): 193-202    DOI: 10.1631/jzus.B0820179
Biomedicine     
Protective effects of Salvia miltiorrhizae on the hearts of rats with severe acute pancreatits or obstructive jaundice
Xi-ping ZHANG, Guang-hua FENG, Jie ZHANG, Yang CAI, Hua TIAN, Xiao-feng ZHANG, Yi-feng ZHOU, Zhi-wei WANG, Ke-yi WANG
Department of General Surgery; Department of Digest; Centralab, Hangzhou First People’s Hospital, Hangzhou 310006, China; The First College of Clinical Medicine, Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, China; Department of General Surgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
Download:     PDF (0 KB)     
Export: BibTeX | EndNote (RIS)      

Abstract  Objective: To investigate the therapeutic effects and mechanisms of Salvia miltiorrhizae (Danshen) in the treatment of severe acute pancreatitis (SAP)- or obstructive jaundice (OJ)-induced heart injury. Methods: A total of 288 rats were used for SAP- (n=108) and OJ-associated (n=180) experiments. The rats were randomly divided into sham-operated, model control, and Salvia miltiorrhizae-treated groups. According to the difference of time points after operation, SAP rats in each group were subdivided into 3, 6 and 12 h subgroups (n=12), whereas OJ rats were subdivided into 7, 14, 21, and 28 d subgroups (n=15). At the corresponding time points after operation, the mortality rates of the rats, the contents of endotoxin and phospholipase A2 (PLA2) in blood, and pathological changes of the hearts were investigated. Results: The numbers of dead SAP and OJ rats in the treated groups declined as compared with those in the model control group, but not significantly (P>0.05). The contents of endotoxin (at 6 and 12 h in SAP rats and on 7, 14, 21, and 28 d in OJ rats, respectively) and PLA2 (at 6 and 12 h in SAP rats and on 28 d in OJ rats, respectively) in the treated group were significantly lower than those in the model control group (P<0.01 and P<0.001, respectively). Besides, myocardial pathological injuries were mitigated in SAP and OJ rats. Conclusion: In this study, we found that Salvia miltiorrhizae improved myocardial pathological changes, reduced the content of PLA2 in blood, and decreased the mortality rates of SAP and OJ rats, exerting protective effects on the hearts of the rats.

Key words： Salvia miltiorrhizae      Traditional Chinese medicine      Severe acute pancreatitis (SAP)      Obstructive jaundice (OJ)      Heart     
Received: 29 May 2008     
CLC:  R5  
Service
E-mail this article
Add to my bookshelf
Add to citation manager
E-mail Alert
RSS
Articles by authors
Ke-yi WANG
Xi-ping ZHANG
Guang-hua FENG
Jie ZHANG
Yang CAI
Hua TIAN
Xiao-feng ZHANG
Yi-feng ZHOU
Zhi-wei WANG
Cite this article:

Xi-ping ZHANG, Guang-hua FENG, Jie ZHANG, Yang CAI, Hua TIAN, Xiao-feng ZHANG, Yi-feng ZHOU, Zhi-wei WANG, Ke-yi WANG. Protective effects of Salvia miltiorrhizae on the hearts of rats with severe acute pancreatits or obstructive jaundice. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2009, 10(3): 193-202.

URL:

http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B0820179     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2009/V10/I3/193

[1] Mélanie Poivre, Pierre Duez. Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2017, 18(3): 194-214.
[2] Da Yuan, Xue Yang, Jun-chao Guo. A great honor and a huge challenge for China: You-you TU getting the Nobel Prize in Physiology or Medicine[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2016, 17(5): 405-408.
[3] De-xing Hu, Xian-bao Liu, Wen-chao Song, Jian-an Wang. Roles of SIRT3 in heart failure: from bench to bedside[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2016, 17(11): 821-830.
[4] Hao Lu, Wen-zhi Pan, Quan Wan, Lei-lei Cheng, Xian-hong Shu, Cui-zhen Pan, Ju-ying Qian, Jun-bo Ge. Trends in the prevalence of heart diseases over a ten-year period from single-center observations based on a large echocardiographic database[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2016, 17(1): 54-59.
[5] Hao-jian Dong, Cheng Huang, De-mou Luo, Jing-guang Ye, Jun-qing Yang, Guang Li, Jian-fang Luo, Ying-ling Zhou. Concomitant coronary and renal revascularization improves left ventricular hypertrophy more than coronary stenting alone in patients with ischemic heart and renal disease[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2016, 17(1): 67-75.
[6] Zhen-kun Yang, Chen Ying, Hong-yan Zhao, Yue-hua Fang, Ying Chen, Wei-feng Shen. Mineral metabolism disturbances are associated with the presence and severity of calcific aortic valve disease[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2015, 16(5): 362-369.
[7] Jian-nong Wu, Tie-er Gan, Yue-xian Zhu, Jun-min Cao, Cong-hua Ji, Yi-hua Wu, Bin Lv. Epidemiology and microbiology of nosocomial bloodstream infections: analysis of 482 cases from a retrospective surveillance study[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2015, 16(1): 70-77.
[8] Hui-yong Peng, Chang-feng Man, Juan Xu, Yu Fan. Elevated homocysteine levels and risk of cardiovascular and all-cause mortality: a meta-analysis of prospective studies[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2015, 16(1): 78-86.
[9] Ji-jia Liu, Liang-liang Fan, Jin-lan Chen, Zhi-ping Tan, Yi-feng Yang. A novel variant in TBX20 (p.D176N) identified by whole-exome sequencing in combination with a congenital heart disease related gene filter is associated with familial atrial septal defect[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2014, 15(9): 830-837.
[10] Kang Chen, Ye Mao, Shao-hua Liu, Qiong Wu, Qing-zhi Luo, Wen-qi Pan, Qi Jin, Ning Zhang, Tian-you Ling, Ying Chen, Gang Gu, Wei-feng Shen, Li-qun Wu. Is right ventricular mid-septal pacing superior to apical pacing in patients with high degree atrio-ventricular block and moderately depressed left ventricular function?[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2014, 15(6): 507-514.
[11] Yi-chen Yang, Fa-rong Shen, Yuan-qiang Lu. Hypocalcemia: a reversible cause of T wave alternans and heart failure[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2014, 15(6): 598-600.
[12] Yun-liang Zang, Ling Xia. Cellular mechanism of cardiac alternans: an unresolved chicken or egg problem[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2014, 15(3): 201-211.
[13] Xian-bao Liu, Jian-an Wang. Update of transcatheter valve treatment[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2013, 14(8): 670-675.
[14] Jing Wang, Tao Guo. Metabolic remodeling in chronic heart failure[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2013, 14(8): 688-695.
[15] Qiang Liu, Xiao-jia Su, Yan Yu, Yong-lin Liu. Correlation between virus persistent infection and cardic function in patients with dilated cardiomyopathy[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2013, 14(8): 749-753.