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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2016, Vol. 17 Issue (1): 54-59    DOI: 10.1631/jzus.B1500136
Article     
Trends in the prevalence of heart diseases over a ten-year period from single-center observations based on a large echocardiographic database
Hao Lu1,Wen-zhi Pan1,Quan Wan2,Lei-lei Cheng2,?(),Xian-hong Shu2,Cui-zhen Pan2,Ju-ying Qian1,Jun-bo Ge1,?()
1 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China
2 Department of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China
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Abstract  

There is a paucity of data regarding trends in the incidence of heart disease in China during recent years. Using a large echocardiography database in our center, we analyzed trends in the prevalence of several common heart diseases from Dec. 2003. This study retrospectively analyzed the echocardiographic database in our Department from 2003 to 2012. A total of 385 682 cases were included in the study. The prevalence of rheumatic heart disease decreased over the 10-year period, from 4.04% in 2003 to 3.06% in 2012 (P<0.01). Infective endocarditis also decreased, from a mean prevalence of 0.37% in July 2003 to 0.27% in Dec. 2008 (P<0.001). The prevalence of hypertrophic cardiomyopathy, which includes 20% apical hypertrophic cardiomyopathy and 20% hypertrophic obstructive cardiomyopathy, was about 1.8%. The prevalence of the three most common adult congenital heart diseases (CHDs) decreased by about 10% from July 2003 to Dec. 2008 (all P<0.001). The prevalence of moderate pulmonary arterial hypertension (PAH) or left ventricular systolic dysfunction (LVSD) decreased during the 10-year period (P<0.001), but there was no change in the prevalence of severe PAH or LVSD (P>0.05). The present study indirectly demonstrates that the prevalence of several common heart diseases in China has declined in recent years.

Key words： Prevalence      Trends      Heart diseases      Epidemiology     
Received: 01 June 2015      Published: 01 January 2016
Fund:  Project supported by the National Natural Science Foundation of China(Nos. 81400318, 81300209)
Corresponding Authors: Lei-lei Cheng,Jun-bo Ge     E-mail: cheng.leilei@zs-hospital.sh.cn;jbge@zs-hospital.sh.cn
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Hao Lu
Wen-zhi Pan
Quan Wan
Lei-lei Cheng
Xian-hong Shu
Cui-zhen Pan
Ju-ying Qian
Jun-bo Ge
Cite this article:

Hao Lu,Wen-zhi Pan,Quan Wan,Lei-lei Cheng,Xian-hong Shu,Cui-zhen Pan,Ju-ying Qian,Jun-bo Ge. Trends in the prevalence of heart diseases over a ten-year period from single-center observations based on a large echocardiographic database. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2016, 17(1): 54-59.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1500136     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2016/V17/I1/54

Year Number of case Male (%) Age (year) Total number of outpatient visits (person-time) Percentage of outpatient undergoing ECG (%)
2003 11 086 51.19 49.38±17.88 80 856 13.71
2004 14 656 52.32 54.39±16.06 103 526 14.16
2005 23 655 51.00 54.28±16.06 153 420 15.42
2006 28 210 50.54 54.81±16.36 184 755 15.27
2007 36 926 49.12 55.21±16.19 244 555 15.10
2008 46 414 49.94 55.47±18.61 293 538 15.81
2009 53 145 49.49 55.76±16.10 334 517 15.89
2010 54 247 51.42 55.87±15.84 375 271 14.45
2011 55 597 50.56 57.08±15.69 394 918 14.08
2012 61 746 51.80 57.10±16.50 423 561 14.57
Table 1 Demographic characteristics of outpatients undergoing transthoracic echocardiogram examination in our department from 2003 to 2012
Disease Prevalence of several common heart diseases (%)
 Change* (%) P **
2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 First 5 years Last 5 years
?RHD 4.04 5.49 3.73 3.71 3.43 3.11 2.91 3.10 3.05 3.06 3.87 3.04 ?21.47 <0.001
?IE 0.47 0.48 0.27 0.41 0.31 0.27 0.20 0.29 0.30 0.31 0.35 0.26 ?25.56 <0.001
?Post valve surgery 5.16 5.04 4.72 3.38 4.11 4.32 4.38 4.36 4.62 4.40 4.18 4.42 5.79 0.002
?Non-RHD VHD 4.66 5.15 5.01 4.27 4.27 4.33 3.82 4.64 4.54 4.65 4.67 4.33 ?7.68 0.006
?HOCM 0.32 0.42 0.37 0.37 0.33 0.29 0.37 0.42 0.48 0.45 0.37 0.40 8.41 0.008
?HNOCM 0.89 1.35 1.08 1.23 0.95 0.94 0.95 1.11 1.15 0.99 1.11 1.04 ?6.31 0.064
?ApHCM 0.39 0.33 0.34 0.32 0.25 0.16 0.29 0.52 0.33 0.69 0.30 0.33 10.01 0.202
?Total of HCM 1.60 2.10 1.79 1.92 1.53 1.39 1.61 2.05 2.17 2.14 1.78 1.76 ?1.12 0.784
?ARVD 0.00 0.00 0.00 0.00 0.01 0.01 0.00 0.01 0.01 0.02 0.00 0.01 67.96 0.370
?RCM 0.00 0.01 0.02 0.01 0.01 0.02 0.02 0.05 0.03 0.06 0.01 0.03 216.17 <0.001
?NCVM 0.02 0.05 0.02 0.04 0.03 0.02 0.05 0.08 0.06 0.04 0.04 0.05 36.83 0.016
?ASD 3.10 2.89 2.42 2.34 2.20 2.23 2.26 2.03 2.19 2.34 2.38 2.27 ?5.90 <0.001
?VSD 2.11 1.88 1.40 1.47 1.27 1.45 1.28 1.15 1.12 1.21 1.44 1.24 ?13.73 <0.001
?PDA 0.78 0.76 0.59 0.57 0.53 0.53 0.52 0.55 0.48 0.54 0.59 0.52 ?11.52 0.017
?ASD+VSD+PDA 5.99 5.53 4.40 4.39 4.00 4.21 4.07 4.09 3.80 4.09 4.41 3.94 ?10.82 <0.001
?BAV 0.65 0.85 0.61 0.74 0.55 0.62 0.74 0.79 0.90 1.08 0.65 0.72 9.24 0.058
?CHD associated PAH 1.71 1.30 1.14 1.22 1.02 0.91 0.85 0.82 0.83 0.97 1.14 0.85 ?25.65 <0.001
?Other types of PAH 7.73 9.40 5.50 7.58 6.82 5.70 3.64 6.22 5.98 6.06 7.09 5.39 ?24.01 <0.001
?Moderate PAH 7.48 8.54 6.64 7.09 6.18 5.09 4.79 5.21 5.01 5.31 6.87 5.02 ?26.87 <0.001
?Severe PAH 1.96 2.16 1.53 1.71 1.66 1.52 1.59 1.83 1.81 1.72 1.72 1.69 ?1.37 0.638
?Moderate LVSD 4.26 4.23 4.27 4.19 3.44 3.22 3.34 3.33 3.64 3.12 3.94 3.39 ?14.20 <0.001
?Severe LVSD 0.92 0.96 0.96 0.76 0.66 0.61 0.91 0.89 0.90 1.17 0.79 0.84 5.04 0.256
Table 2 Trends in the prevalence of several common heart diseases in China from 2003 to 2012
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