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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2010, Vol. 11 Issue (5): 315-322    DOI: 10.1631/jzus.B0900364
Biotechnology     
Inhibitory effect of Jeju endemic seaweeds on the production of pro-inflammatory mediators in mouse macrophage cell line RAW 264.7
Eun-Jin Yang, Ji-Young Moon, Min-Jin Kim, Dong Sam Kim, Chan-Shick Kim, Wook Jae Lee, Nam Ho Lee, Chang-Gu Hyun
Jeju Biodiversity Research Institute (JBRI), Jeju High-Tech Development Institute (HiDI), Jeju 699-943, Korea, Jeju Seaweed Industry Development Agency, Cheju National University, Jeju 690-756, Korea, Faculty of Biotechnology, Cheju National University, Jeju 690-756, Korea, Department of Chemistry, Cheju National University, Jeju 690-756, Korea
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Abstract  Seaweed has been used in traditional cosmetics and as a herbal medicine in treatments for cough, boils, goiters, stomach ailments, and urinary diseases, and for reducing the incidence of tumors, ulcers, and headaches. Despite the fact that seaweeds are frequently used in the practice of human health, little is known about the role of seaweed in the context of inflammation. This study aimed to investigate the influence of Jeju endemic seaweed on a mouse macrophage cell line (RAW 264.7) under the stimulation of lipopolysaccharide (LPS). Ethyl acetate extracts obtained from 14 different kinds of Jeju seaweeds were screened for inhibitory effects on pro-inflammatory mediators. Our results revealed that extracts from five seaweeds, Laurencia okamurae, Grateloupia elliptica, Sargassum thunbergii, Gloiopeltis furcata, and Hizikia fusiformis, were potent inhibitors of the production of pro-inflammatory mediators such as nitric oxide (NO), prostaglandin E2 (PGE2), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α). Based on these results, the anti-inflammatory effects and low cell toxicity of these seaweed extracts suggest potential therapeutic applications in the regulation of the inflammatory response.

Key words： Nitric oxide      Interleukin-6 (IL-6)      Prostaglandin E2 (PGE2)      Tumor necrosis factor-α      (TNF-α)      Seaweeds      Pro-inflammatory mediators     
Received: 13 November 2009      Published: 28 April 2010
CLC:  Q94  
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Eun-Jin Yang
Ji-Young Moon
Min-Jin Kim
Dong Sam Kim
Chan-Shick Kim
Wook Jae Lee
Nam Ho Lee
Chang-Gu Hyun
Cite this article:

Eun-Jin Yang, Ji-Young Moon, Min-Jin Kim, Dong Sam Kim, Chan-Shick Kim, Wook Jae Lee, Nam Ho Lee, Chang-Gu Hyun. Inhibitory effect of Jeju endemic seaweeds on the production of pro-inflammatory mediators in mouse macrophage cell line RAW 264.7. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2010, 11(5): 315-322.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B0900364     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2010/V11/I5/315

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