| Biomedicine |
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| Proteomic analysis of the serum in patients with idiopathic pulmonary arterial hypertension |
| YU Min, WANG Xing-xiang, ZHANG Fu-rong, SHANG Yun-peng, DU Yu-xi, CHEN Hong-juan, CHEN Jun-zhu |
| Department of Cardiovascular Disease, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; Department of Cardiovascular Disease, Taizhou Hospital, Taizhou 317000, China |
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Abstract Idiopathic pulmonary arterial hypertension (IPAH) is a rare disease of unknown etiology. The exact pathogenesis of pulmonary arterial hypertension is still not well known. In the past decades, many protein molecules have been found to be involved in the development of IPAH. With proteomic techniques, profiling of human plasma proteome becomes more feasible in searching for disease-related markers. In present study, we showed the protein expression profiles of the serum of IPAH and healthy controls after depleting a few high-abundant proteins in serum. Thirteen spots had changed significantly in IPAH compared with healthy controls and were identified by LC-MS/MS. Alpha-1-antitrypsin and vitronectin were down-regulated in IPAH and may be valuable candidates for further explorations of their roles in the development of IPAH.
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Received: 19 January 2007
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