Please wait a minute...
ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2011, Vol. 12 Issue (2): 135-142    DOI: 10.1631/jzus.B1000117
Biotechnology     
Evaluation of the hepatoprotective and antioxidant activities of Rubus parvifolius L.
Jie Gao, Cui-rong Sun, Jie-hong Yang, Jian-mei Shi, Yue-guang Du, Yu-yan Zhang, Jin-hui Li, Hai-tong Wan
Department of Chemistry, Zhejiang University, Hangzhou 310027, China; Institute of Cardio-Cerebrovascular Disease, Zhejiang Chinese Medical University, Hangzhou 310053, China
Download:     PDF (0 KB)     
Export: BibTeX | EndNote (RIS)      

Abstract  The hepatoprotective and antioxidant activities of the n-butanol extract of Rubus parvifolius L. (RPL), a widely used medicinal plant, were evaluated. Results demonstrated that RPL extract possessed pronounced hepatoprotective effects against carbon tetrachloride (CCl4)-induced hepatic injury in mice, which was at least partially attributed to its strong antioxidant capacity. Treatment with RPL extract markedly attenuated the increases in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels caused by CCl4 intoxication. It also significantly prevented the decrease in superoxide dismutase (SOD) activity and the increase in malondialdehyde (MDA) content of liver tissue. Meanwhile, histopathological changes of hepatic damage were also remarkably ameliorated. Phytochemical analysis based on high-performance liquid chromatography/tandem mass spectrometry (HPLC-MS/MS) revealed the presence of various phenolic compounds, including caffeic acid conjugates, ellagic acid glycosides, and flavonol glycosides, which might be responsible for the hepatoprotective and antioxidant activities of RPL.

Key words： Rubus parvifolius L.      High-performance liquid chromatography/tandem mass spectrometry (HPLC-MS/MS)      Hepatoprotective activity      Antioxidant activity     
Received: 30 March 2010      Published: 04 February 2011
CLC:  R962  
  Q65  
Service
E-mail this article
Add to my bookshelf
Add to citation manager
E-mail Alert
RSS
Articles by authors
Jie Gao
Cui-rong Sun
Jie-hong Yang
Jian-mei Shi
Yue-guang Du
Yu-yan Zhang
Jin-hui Li
Hai-tong Wan
Cite this article:

Jie Gao, Cui-rong Sun, Jie-hong Yang, Jian-mei Shi, Yue-guang Du, Yu-yan Zhang, Jin-hui Li, Hai-tong Wan. Evaluation of the hepatoprotective and antioxidant activities of Rubus parvifolius L.. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2011, 12(2): 135-142.

URL:

http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1000117     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2011/V12/I2/135

[1] Fei Han, Guang-qiang Ma, Ming Yang, Li Yan, Wei Xiong, Ji-cheng Shu, Zhi-dong Zhao, Han-lin Xu. Chemical composition and antioxidant activities of essential oils from different parts of the oregano[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2017, 18(1): 79-84.
[2] Zhuo-ping Yu, Dong-dong Xu, Lai-feng Lu, Xiao-dong Zheng, Wei Chen. Immunomodulatory effect of a formula developed from American ginseng and Chinese jujube extracts in mice[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2016, 17(2): 147-157.
[3] Tao Bao, Ye Wang, Yu-ting Li, Vemana Gowd, Xin-he Niu, Hai-ying Yang, Li-shui Chen, Wei Chen, Chong-de Sun. Antioxidant and antidiabetic properties of tartary buckwheat rice flavonoids after in vitro digestion[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2016, 17(12): 941-951.
[4] Sitthichai Iamsaard, Jaturon Burawat, Pipatpong Kanla, Supatcharee Arun, Wannisa Sukhorum, Bungorn Sripanidkulchai, Nongnut Uabundit, Jintanaporn Wattathorn, Wiphawi Hipkaeo, Duriya Fongmoon, Hisatake Kondo. Antioxidant activity and protective effect of Clitoria ternatea flower extract on testicular damage induced by ketoconazole in rats[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2014, 15(6): 548-555.
[5] Sitthichai Iamsaard, Supatcharee Arun, Jaturon Burawat, Wannisa Sukhorum, Jintanaporn Wattanathorn, Somsak Nualkaew, Bungorn Sripanidkulchai. Phenolic contents and antioxidant capacities of Thai-Makham Pom (Phyllanthus emblica L.) aqueous extracts[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2014, 15(4): 405-408.
[6] Yue-fei Wang, Jie Wang, Jing Wu, Ping Xu, Yi-qi Wang, Jun-jie Gao, Danielle Hochstetter. In vitro antioxidant activity and potential inhibitory action against α-glucosidase of polysaccharides from fruit peel of tea (Camellia sinensis L.)[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2014, 15(2): 173-180.
[7] Yong-liang ZHUANG, Xue ZHAO, Ba-fang LI. Optimization of antioxidant activity by response surface methodology in hydrolysates of jellyfish (Rhopilema esculentum) umbrella collagen[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2009, 10(8): 572-579.
[8] Jing ZHOU, Nan HU, Ya-lin WU, Yuan-jiang PAN, Cui-rong SUN. Preliminary studies on the chemical characterization and antioxidant properties of acidic polysaccharides from Sargassum fusiforme[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2008, 9(9): 721-727.