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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2005, Vol. 6 Issue ( 9): 7-    DOI: 10.1631/jzus.2005.B0885
    
Pharmacokinetics of mycophenolic acid in Chinese kidney transplant patients
LU Xiao-yang, HUANG Hong-feng, SHENG-TU Jian-zhong, LIU Jian
Department of Clinical Pharmacology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
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Abstract  To assess the influence of cyclosporin A (CsA) and tacrolimus (FK506) on mycophenolic acid (MPA) and correlation analysis of the pharmacokinetic parameters and patient characteristics, clinical outcome in Chinese kidney transplant recipients, the pharmacokinetics of 1000 mg mycophenolate mofetil (MMF) twice daily was measured by high-performance liquid chromatography (HPLC). PKS (Pharmaceutical Kinetics Software) 1.0.2 software package was used for the calculation of pharmacokinetic parameters. The mean Cmax, tmax, and AUC(0−12)were (21.88±10.52) µg/ml, (1.20±0.95) h, and (52.546±13.215) µg·h/ml, respectively. The level of AUC(0−12) in the FK506 group was significantly higher than that in the CsA group. MPA appeared not to be affected by renal function. MPA AUC(0−12) showed statistically significant difference according to the patient’s gender.

Key words： Mycophenolate mofetil      Mycophenolic acid      Pharmacokinetics      Kidney transplant     
Received: 21 June 2005     
CLC:  R9  
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LU Xiao-yang
HUANG Hong-feng
SHENG-TU Jian-zhong
LIU Jian
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LU Xiao-yang, HUANG Hong-feng, SHENG-TU Jian-zhong, LIU Jian. Pharmacokinetics of mycophenolic acid in Chinese kidney transplant patients. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2005, 6( 9): 7-.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.2005.B0885     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2005/V6/I 9/7

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