| Biotechnology |
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| Pharmacokinetics of gemcitabine in Chinese patients with non-small-cell lung cancer |
| WANG Lin-run, HUANG Ming-zhu, XU Nong, SHENTU Jian-zhong, LIU Jian, CAI Jie |
| First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China |
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Abstract To determine the pharmacokinetics of gemcitabine (2′,2′-difluorodeoxycytidine) in Chinese non-small-cell lung cancer (NSCLC) patients. Six study subjects were administered gemcitabine at a fixed dose rate of 10 mg/m2 per min (1200 mg/m2, two hours infusion), and carboplatin and plasma gemcitabine concentrations were measured by ion-pair reversed-phase high-performance liquid chromatography (HPLC). 3P97 Pharmaceutical Kinetics Software was used for the calculation of pharmacokinetic parameters. The obtained mean parameters, elimnation half life (t1/2) (10.67±3.38 min), area under the curve (AUC) (7.55±1.53 (µg·h)/ml), and clearance (CL) (3940.05±672.08 ml/min), were consistent with those reported in literature. The hematologic toxicology result showed that the regimen was effective on and tolerated by the patients.
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Received: 02 February 2005
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