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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2017, Vol. 18 Issue (4): 343-352    DOI: 10.1631/jzus.B1600235
Articles     
Effect of compatible herbs on the pharmacokinetics of effective components of Panax notoginseng in Fufang Xueshuantong Capsule
Huan-huan Pang, Meng-yi Li, Yuan Wang, Min-ke Tang, Chang-hua Ma, Jian-mei Huang
School of Chinese Material Medica, Beijing University of Chinese Medicine, Beijing 100102, China
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Abstract  Fufang Xueshuantong (FXT) is a well-known Chinese herbal formula which has been used to treat cardiovascular and ophthalmic diseases, especially diabetic retinopathy. Panax notoginseng (Burkill) F.H. Chen (PN) is the main herb of FXT, whose major bioactive constituents are ginsenosides. However, the scientific basis of the compatibility of FXT is still ambiguous. The present study investigated the scientific basis of the compatibility of FXT by comparing the pharmacokinetics of marker compounds after oral administrations of PN and FXT. A high performance liquid chromatography-electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) method was developed for simultaneous detection of notoginsenoside R1 (NR1), ginsenoside Rg1 (GRg1), and ginsenoside Rb1 (GRb1) in rat plasma. The pharmacokinetic studies of FXT and PN were performed using the established method with the pharmacokinetic parameters being determined by non-compartmental analysis. The results showed that the pharmacokinetic parameters (maximum concentration, area under the curve (AUC0–t), clearance, and mean residence time) of NR1, GRg1, and GRb1 were significantly different after oral administration of FXT (P<0.05) compared with PN. The AUC0–t values of GRg1 and GRb1 were 1.7- and 3.4-fold greater, respectively, in FXT than in PN. The compatible herbs of FXT could prolong the retention time and increase the systemic exposure of NR1, GRg1, and GRb1 compared with PN in vivo, providing some scientific basis for the compatibility and clinical use of FXT.

Key words： Fufang Xueshuantong      Panax notoginseng      Pharmacokinetics      Compatibility     
Received: 23 May 2016      Published: 05 April 2017
CLC:  R28  
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Huan-huan Pang
Meng-yi Li
Yuan Wang
Min-ke Tang
Chang-hua Ma
Jian-mei Huang
Cite this article:

Huan-huan Pang, Meng-yi Li, Yuan Wang, Min-ke Tang, Chang-hua Ma, Jian-mei Huang. Effect of compatible herbs on the pharmacokinetics of effective components of Panax notoginseng in Fufang Xueshuantong Capsule. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2017, 18(4): 343-352.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1600235     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2017/V18/I4/343

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