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JOURNAL OF ZHEJIANG UNIVERSITY (ENGINEERING SCIENCE)
Mechanical and Electrical Engineering     
Theoretical and experimental study on capillary burst valve under centrifugal environment
SHEN Teng, WANG Jiong, HUANG Liu
College of Mechanical Engineering, Nanjing University of Science and Technology,Nanjing 210094,China
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Abstract  

The process of breaking through the passive valve was analyzed in order to predict the burst pressure for capillary valve based on the interfacial energy equation. The fundamentals of hydrophilic capillary valve in a rectangular microchannel were analyzed. The process of breaking through the passive valve was divided into three stages according to the different central angle on the bending surface, Then the three-dimensional (3D) theory on the burst pressure was canducted. The microfluidic chips were fabricated from layers of polymethyl methacrylate (PMMA) plastic for comparing the different burst pressure models. Experimental apparatus was developed for visualization and measurements of the liquid flow in the microfluidic chip equipped with a capillary valve. Results showed that the measurements of burst pressure for the capillary valves accorded with the predictions by the 3D theory model. The three stages can describe the process of breaking through the passive valve more reasonably.



Published: 01 August 2016
CLC:  TH 703  
  TH 134.1  
Cite this article:

SHEN Teng, WANG Jiong, HUANG Liu. Theoretical and experimental study on capillary burst valve under centrifugal environment. JOURNAL OF ZHEJIANG UNIVERSITY (ENGINEERING SCIENCE), 2016, 50(8): 1578-1584.

URL:

http://www.zjujournals.com/eng/10.3785/j.issn.1008-973X.2016.08.021     OR     http://www.zjujournals.com/eng/Y2016/V50/I8/1578


离心环境下毛细被动阀的理论与实验

为了更好地预测毛细被动阀的突破压力,对液体的突破过程进行研究.利用液体界面能方程,分析毛细被动阀的工作原理.根据弯曲面所对应圆心角的不同,将液体的突破过程划分为3个阶段,对亲水被动阀在矩形微通道中的突破压力进行三维理论分析.利用聚甲基丙烯酸甲酯(PMMA)为基材,制作了离心式被动阀芯片.通过可视化离心平台得到了被动阀的突破频率,与不同的三维突破模型进行对比分析.研究结果表明,该三维模型对被动阀突破压力有着较准确的预测|模型所划分的不同突破阶段可以合理地描述被动阀的突破过程.

[1] MADOU M J, LU Y, LAI S, et al. A novel design on a CD disc for 2-point calibration measurement [J]. Sensors and Actuators A: Physical, 2001, 91(3): 301-306.
[2] AUROUX P A, IOSSIFIDIS D, REYES D R, et al. Micro total analysis systems. 2. Analytical standard operations and applications [J]. Analytical Chemistry, 2002, 74(12): 2631-2652.
[3] 范建华,邓永波,宣明,等.CDlike全血分析芯片内压缩空气的定量泵送[J].光学精密工程,2014,22(10):2733-2739.
[3] FAN Jianhua, DENG Yongbo, XUAN Ming,et al. Penumaticpumping metering in CDlike microfluidic chip for whole blood analysis [J].Optics and Precision Engineering ,2014,22(10):2733-2739.
[4] MADOU M J, ZOVAL J, JIA G, et al. Lab on a CD [J]. Annual review of Biomedical Engineering, 2006, 8(1): 601-628.
[5]KIM J, KIDO H, RANGEL R H, et al. Passive flow switching valves on a centrifugal microfluidic platform [J]. Sensors and actuators B: Chemical, 2008, 128(2): 613621.
[6] HUANG Y C, SUNG W L, LAI W C, et al. Design and implementation of timedelay switch triggered by inertia load[C]∥Micro Electro Mechanical Systems (MEMS). 2013 IEEE 26th International Conference on. Tsipei China: IEEE, 2013: 729-732.
[7] SEN P, KIM C J. A fast liquidmetal droplet microswitch using ewoddriven contactline sliding [J]. Journal of Microelectromechanical Systems,2009, 1(18): 174-185.
[8] 杜新,张平,刘永顺,等.基于PDMS和玻璃材料的毛细管被动阀临界压力分析[J].光学精密工程,2011,19(8): 1852-1858.
DU Xin,ZHANG Ping,LIU Yongshun,et al.Burst pressure of capillary burst valve based on glass and PDMS [J].Optics and Precision Engineering, 2011,19(8): 1852-1858.
[9] MELIN J, ROXHED N, GIMENEZ G,et al. A liquidtriggered liquid microvalve for onchip flow control [J].Sensors and Actuators B,100(2004), 463-468.
[10] KAZEMZADEH A, GANESAN P, LBRAHIM F,et al.Guided routing on spinning microfluidic platforms [J].RSC Advances, 2015, 5, 8669,DOI: 10.1039/c4ra14397c.
[11] ZENG J, BANERJEE D, DESHPANDE M,et al. Design analyses of capillary burst valves in centrifugal microfluidics [C]∥In: Micro Total Analysis Systems 2000.In: Proceedings of the UTAS 2000 Symposium: Enschede: The Netherlands, 2000, 579-582.
[12] DUFFY D C, GILLIS H L, LIN J, et al. Microfabricated centrifugal microfluidic systems: characterization and multiple enzymatic assays[J]. Analytical Chemistry,1999, 71: 4669-4678.
[13] MAN P F, MASTRANGELO C H, BURNS M A,et al. Microfabricated capillarydriven stop valve and sample injector[C]∥In: Proceedings of 11th annual international workshop on microelectro mechanical systems. Heidelberg: \[s.n.\], 1998, pp 45-50.
[14] LEU T S, CHANG P Y. Pressure barrier of capillary stop valves in micro sample separators [J]. Sensors and Actuators A: Physical, 2004, 115(2): 508-515.
[15] CHEN J M, HUANG P C, LIN M G. Analysis and experiment of capillary valves for microfluidics on a rotating disk [J]. Microfluidics and Nanofluidics, 2008, 4(5): 427-437.
[16] CHO H, KIM H Y, KANG J Y, et al. Capillary passive valve in microfluidic systems[C]∥In: Technical Proceedings of the 2004 NSTI Nanotechnology Conference and trade show—NSTI Nanotech 2004. Boston: Massachusetts. Nano Science and Technology Institute (NSTI), 1. 263-266.
[17] THOP T H G, SOROORI S, IBRHIM F, et al. Theoretical development and critical analysis of burst frequency equations for passive valves on centrifugal microfluidic platforms [J]. Medical & Biological Engineering & Computing, 2013, 51(5): 525-535.
[18] CHO H, KIM H Y, KANG J Y, et al. How the capillary burst microvalve works [J]. Journal of Colloid and Interface science, 2007, 306(2): 379-385.5.
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