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浙江大学学报(工学版)
J4  2013, Vol. 47 Issue (5): 901-905    DOI: 10.3785/j.issn.1008-973X.2013.05.024
生物医学工程     
基于偏最小二乘的大鼠初级运动皮层解码
朱凡1,3,李悦1,2,蒋 凯1,叶树明1,郑筱祥1,2
1.浙江大学 生物医学工程教育部重点实验室, 浙江 杭州 310027;2.浙江大学 求是高等研究院, 浙江 杭州 310027;3.浙江农林大学 信息工程学院,浙江 杭州 311300
Decoding of rat’s primary motor cortex by partial least square
ZHU Fan1 , LI Yue1,2, JIANG Kai1, YE Shu-ming1, ZHENG Xiao-xiang2
1. Key Laboratory of Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou 310027,
China|2. Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou 310027, China;
3.Information Engineering College, Zhejiang Agriculture and Forestry University, Hangzhou 311300,China 
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摘要：

为了准确解析大鼠初级运动皮层神经元发放模式并预测相应的肢体动作,实验同时记录大鼠初级运动皮层神经元峰电位发放和大鼠前肢压力,利用K均值法和主成分分析法对神经元进行分类,采用偏最小二乘分析大鼠初级运动皮层神经元活动与前肢运动参数之间的关系,并对该解码结果与维纳滤波和卡尔曼滤波算法的解码结果进行比较.实验结果表明：神经元的发放活动在压杆前0.6 s开始有增加的趋势,提示大鼠的初级运动皮层神经元分布式活动可用于大鼠前肢运动的解析和预测,且偏最小二乘解码得到的预测值与真实压杆值的相关系数在085以上,均高于维纳滤波和卡尔曼滤波的解码结果.
Abstract:

In order to analytizing neurons release pattern of the primary motor cortex of rats accurately and predicting corresponding body movement, the activities of the neurons ensemble spike activities in rats primary motor cortex and the forelimb pressure were recorded simultaneously in the experiment. K-means and principal component analysis were used to classification of neurons, then the partial least squares was used to analyze the relations between the neurons activities of the primary motor cortex of the rat and the forelimb motion parameters, and the results were compared with Wiener filter and Kalman filter. The experimental results indicate that the activities of neurons ensembles began a trend of increase 0.6 second before lever pressing, Which hints the neurons distributed activities of the primary motor cortex in rats can be used to analysis and prediction its forelimb movement and the correlation coefficient between the predicted value and real pressure value is more than 085 using the partial least squares, with a better decoding results than those using the Wiener filtering and Kalman filtering．
出版日期: 2013-05-01
:  TP 391  
基金资助:

国家“973”重点基础研究发展计划资助项目(2011CB504400).
通讯作者: 郑筱祥,女,教授.     E-mail: zxx@mail.bme.zju.edu.cn
作者简介: 朱凡(1979- ), 女,博士,从事生物医学方面信息处理及检测仪器开发. E-mail:zf13675841843@163.com
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引用本文:

朱凡,李悦,蒋 凯,叶树明,郑筱祥. 基于偏最小二乘的大鼠初级运动皮层解码[J]. J4, 2013, 47(5): 901-905.

ZHU Fan , LI Yue, JIANG Kai, YE Shu-ming, ZHENG Xiao-xiang. Decoding of rat’s primary motor cortex by partial least square. J4, 2013, 47(5): 901-905.

链接本文:

http://www.zjujournals.com/eng/CN/10.3785/j.issn.1008-973X.2013.05.024    或    http://www.zjujournals.com/eng/CN/Y2013/V47/I5/901

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