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浙江大学学报(工学版)
J4  2009, Vol. 43 Issue (09): 1684-1686    DOI: 10.3785/j.issn.1008-973X.2009.
化学工程     
管式反应器合成N,N-二甲基正丁胺
张旭,张涛,陈小祥,闫浩,罗明,钱超,陈新志
（浙江大学 化学工程与生物工程学系,浙江 杭州 310027）
Synthesis of N, N-dimethyl-n-butylamine with tubular reactor
ZHANG Xu, ZHANG Tao, CHEN Xiao-xiang, YAN Hao, LUO Min, QIAN Chao, CHEN Xin-zhi
(Department of Chemical and Biochemical Engineering, Zhejiang University, Hangzhou 310027, China)
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摘要：

为了提高N,N-二甲基正丁胺合成方法的经济性与环境友好性,采用以正丁胺与甲醇为主要原料进行催化胺化的路线,原子利用率较高.用浸渍法制备了磷酸改性的γ-Al2O3负载活性金属的催化剂,在管式固定床反应器中考察了催化剂活性成分及反应条件对合成N,N-二甲基正丁胺的影响.结果表明,γ-Al2O3上负载活性组分含Co和Ni质量分数分别为30%～31%及9%～10%的催化剂具有较满意的选择性和活性.在较合适的反应工艺条件：压力为0.3 MPa,温度为160 ℃,体积空速为0.3 h-1,进料甲醇和正丁胺的物质的量比为6∶1下,原料正丁胺的转化率达到81.7%,目标产物N,N-二甲基正丁胺的选择性达到72.9%.
Abstract:

The catalytic amination of n-butylamine and methanol, which is high in atom utilization, was conducted to produce N, N-dimethyl-n-butylamine economically and environmentally. The catalysts were prepared by impregnation of Cu, Ni, Co on the phosphoric acid treated γ-Al2O3 and the processes were studied in a tubular fixed-bed reactor. The characteristics of the catalysts and the reaction conditions were observed experimentally. Results showed that the catalyst with Co mass fraction of 30%～31% and Ni mass fraction of 9%～10% performed better in the amination. The conversion of 81.7% of the n-butylamine and the selectivity of 72.9% for the desired product were obtained under the proper reaction conditions at 0.3 MPa, 160 ℃, 0.3 h-1 and molar ratio of methanol∶butylamine=6∶1．
:  TQ 032-41  
基金资助:

国家“十一五”科技支撑计划资助项目（2007BAI34B07）；国家自然科学基金资助项目（20776127）；浙江省自然科学基金杰出青年团队资助项目（Y4090045,R4090358）；浙江大学第二期国家创新性实验计划资助项目（1020）；浙江大学第十一期SRTP资助项目（1118）.
通讯作者: 陈新志，男，教授.     E-mail: xzchen@zju.edu.cn
作者简介: 张旭（1986-），男，陕西咸阳人，硕士生，从事精细有机产品合成工艺研究.
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引用本文:

张旭, 张涛, 陈小祥, 等. 管式反应器合成N,N-二甲基正丁胺[J]. J4, 2009, 43(09): 1684-1686.

ZHANG Xu, ZHANG Chao, CHEN Xiao-Xiang, et al. Synthesis of N, N-dimethyl-n-butylamine with tubular reactor. J4, 2009, 43(09): 1684-1686.

链接本文:

http://www.zjujournals.com/eng/CN/10.3785/j.issn.1008-973X.2009.    或    http://www.zjujournals.com/eng/CN/Y2009/V43/I09/1684

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