Please wait a minute...
J4  2013, Vol. 47 Issue (12): 2170-2175    DOI: 10.3785/j.issn.1008-973X.2013.12.015
化学工程     
三丁酸甘油酯中维生素A热处理反应产物研究
尹红, 俞安, 盛财平, 袁慎峰, 陈志荣
浙江大学 化学工程与生物工程学系,浙江 杭州 310027
Study on reaction products of vitamin A in tributyrin under heating
YIN Hong, YU An, SHENG Cai-ping, YUAN Shen-feng, CHEN Zhi-rong
Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China
 全文: PDF  HTML
摘要:

为了考察维生素A的稳定性,在避光无氧条件下,采用高效液相色谱(HPLC)及其自带的二极管阵列检测器(DAD)和液质联用仪(HPLC/MS)分析了维生素A醋酸酯(VAA)在三丁酸甘油酯中热处理时生成的副产物类型,跟踪分析了6个不同温度下各物质质量分数随时间的变化情况.研究表明:低温时VAA主要发生异构化反应生成VAA异构体,高温时VAA主要发生异构化反应、脱水反应和二聚反应生成VAA异构体、脱水维生素A和二聚体.

Abstract:

Vitamin A acetate (VAA) was heated at six different temperatures in tributyrin in the absence of oxygen and light in order to investigate the storage stability of vitamin A. HPLC with diode array detector (DAD) and HPLC with mass spectrometer (MS) were applied to analyze the structures of the by-products, and the mass fraction of VAA and various by-products were given with the time progressing as well. It is found that at low temperatures, the isomerization plays a leading role and VAA isomers are the main products; while at high temperatures, three reactions, namely isomerization, dehydration and dimerization, take place in this process, and VAA isomers, anhydrovitamin A and vitamin A dimers are the main products.

出版日期: 2013-12-01
:  TQ 466.1  
基金资助:

国家”863”高技术研究发展计划资助项目(2009AA033301);浙江省重点科技创新团队计划资助项目(2011R50007).

通讯作者: 袁慎峰,男,副教授.     E-mail: ysf@zju.edu.cn
作者简介: 尹红(1971—),女,副教授,从事反应工程和应用化学教学科研工作.E-mail: yinh@zju.edu.cn
服务  
把本文推荐给朋友
加入引用管理器
E-mail Alert
RSS
作者相关文章  

引用本文:

尹红, 俞安, 盛财平, 袁慎峰, 陈志荣. 三丁酸甘油酯中维生素A热处理反应产物研究[J]. J4, 2013, 47(12): 2170-2175.

YIN Hong, YU An, SHENG Cai-ping, YUAN Shen-feng, CHEN Zhi-rong. Study on reaction products of vitamin A in tributyrin under heating. J4, 2013, 47(12): 2170-2175.

链接本文:

http://www.zjujournals.com/eng/CN/10.3785/j.issn.1008-973X.2013.12.015        http://www.zjujournals.com/eng/CN/Y2013/V47/I12/2170

[1] 中华人民共和国卫生部.GB14880-1994 食品营养强化剂使用卫生标准\
[S\].北京:中国标准出版社,1994.

[2] FLANAGAN J, KORTEGAARD K, PINDER D, et al. Solubilisation of soybean oil in microemulsions using var-ious surfactants[J]. Food Hydrocolloids, 2006, 20(2/3): 253-260.

[3] FLANAGAN J, SINGH H. Microemulsions: a potential delivery system for bioactives in food [J]. Critical Reviews in Food Science and Nutrition, 2006, 46(3): 221-237.

[4] YOSHIDA K, SEKINE T, MATSUZAKI F, et al. Stability of vitamin A in oil-in-water-in-oil-type multiple emulsions[J]. Journal of the American Oil Chemists’ Society, 1999, 76 (2): 195-200.

[5] MULLER R H, MADER K, GOHLA S. Solid lipid nanoparticles for controlled drug delivery-a review of the state of the art[J]. European Journal of Pharmaceutics and Biopharmaceutics, 2000, 50(1): 161-177.

[6] 许清清,田克情. 维生素A1-β-环糊精包合物的制备及其稳定性研究[J]. 河北化工, 2009, 32(8): 10.

XU Qing-qing, TIAN Ke-qing. Study on the preparation and stability of vitamin A1-β-cyclodextrin[J].Hebei Chemical Engineering and Industry, 2009, 32(8): 10.

[7] CIRPANLI Y, UNLU N, CALIS S, et al. Formulation and in-vitro characterization of retinoic acid loaded poly(lactic-co-glycolic acid) microspheres[J]. Journal of Microencapsulation, 2005, 22 (8): 877-889.

[8] JEONG Y I, SONG J G, KANG S S, et al. Preparation of poly(DL-lactide-co-glycolide) microspheres encapsulating all-trans retinoic acid[J]. International Journal of Pharmaceutics, 2003, 259(12): 79-91.

[9] FRANK E, RUNGE R, ROBERT H. Use of Microcalorimetry in monitoring stability studies. example: vitamin A esters [J]. Journal of Agricultural and Food Chemistry, 2000, 48: 47-55.

[10] 颜景超,任国谱,赖鸣宇,等.维生素A酯类的稳定性及热降解动力学研究[J].食品工业科技,2010, 31(9): 73-77.

YAN Jing-chao, REN Guo-pu, LAI Ming-yu, et al. Study on stability of retinol esters and their thermal degradation kinetics[J]. Science and Technology of Food Industry, 2010, 31(9): 73-77.

[11] 黄量,于德泉.紫外光谱在有机化学中的应用(上册)[M].北京:科学出版社,2000: 45-119.

[12] BARUA R K, NAYAR P G. Naturally occurring Anhydrovitamin A2.transformation into retinene2[J]. Biochemical Journal, 1966, 101: 302.

[13] TESORIERE L, DARPA D, RE R, et al. Antioxidant reactions of all-trans retinol in phospholipid bilayers: effect of oxygen partial pressure, radical fluxes, and retinol concentration [J]. Archives of Biochemistry and Biophysics, 1997, 343(1): 13-18.

[14] 刘巧云,梅连瑞,朱晓晴,等. 维生素A在胶束溶液中衰变动力学及机理研究[J]. 高等学校化学学报, 2009, 30(2): 297-301.

LIU Qiao-yun, MEI Lian-rui, ZHU Xiao-qing. Kinetics and mechan ism studies of the decay of retinol and retinol acetate in micellar solution[J]. Chemical Journal of Chinese Universities, 2009, 30(2): 297-301.

[1] 尹红, 俞安, 袁慎峰, 陈志荣. 维生素A醋酸酯热处理下结构变化研究[J]. J4, 2013, 47(4): 728-734.