The integrated finite element model consisting of the rotor, the nacelle, the tower and the basis of 5 MW new generation wind turbine system was established. The harmony superposition method and blade-element momentum (BEM) theory were used to calculate the simulation of wind loads on tower-rotor system, which considers the rotational effect, tower-blades modal and aerodynamic interaction effects. The wind-induced responses, equivalent static wind load (ESWL) and dynamic amplified coefficients of wind turbine tower-rotor system were analyzed combined with the calculating method, which could consider the coupled effect between the resonant modes, and the cross term of resonant and background responses. Results showed that the wind-induced responses and ESWL were characterized with complicated wind loads, multimode buffeting responses, and multiple equivalent objectives for equivalent static wind loads. The resonant component had more contribution to wind-induced response and ESWL in middle-upper part and wind rotors. The background responses were similar with the resonant responses in the bottom tower. Cross term between background and resonant components had important effect.