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浙江大学学报(工学版)
J4  2012, Vol. 46 Issue (2): 359-365    DOI: 10.3785/j.issn.1008-973X.2012.02.028
生物医学工程、光学工程     
心肌组织传感阵列在信号传导及药物分析中的应用
陈庆梅1,2, 李蓉1, 肖丽丹1, 刘清君1, 王平1
1. 浙江大学 生物医学工程系,生物传感器国家专业实验室,生物医学工程教育部重点实验室 浙江 杭州 310027；
2. 江西中医学院 医疗电子学科组,江西 南昌 330006
Cardiac tissue-based sensing array for studying on signal
conduction and drugs analysis
CHEN Qing-mei1,2, LI Rong1, XIAO Li-dan1, Liu Qing-jun1, WANG Ping1
1. Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Ministry of Education,
Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China; 2. Department of
medical electronics, Jiangxi Institute of Traditional Chinese Medicine, Nanchang 330006, China
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摘要：

为了对心肌组织的搏动信号及其传导进行实时监测与分析,设计一种用于离体心肌组织电生理检测的组织传感阵列.根据组织/器件耦合原理,该传感阵列能够检测伴随心肌细胞搏动产生的场电位的变化.利用组织传感阵列,同步采集多通道的心肌信号并观察心血管药物盐酸肾上腺素和氯化乙酰胆碱对搏动信号的影响.实验结果显示：离体心肌组织及切片表现出良好的搏动和信号传导；盐酸肾上腺素和氯化乙酰胆碱对心肌组织搏动信号的幅度、频率、持续时间甚至信号的传导分别表现出兴奋和抑制作用.说明组织传感阵列技术对离体心肌组织搏动信号的提取是可行的,并且对心肌信号的传导及药物作用分析非常有用.
Abstract:

To real-time monitor the beating signals of the cardiac tissues and investigate the signal propagation, an in vitro cardiac tissuebased sensing array was developed for monitoring the electrophysiological activities. According to the coupling principle between tissues and sensors, the sensing array can detect the changes of the field potentials with the mechanical beatings of the cardiac cells. With the tissue-based sensing array, the multi-channel data was acquired synchronously and the effect of Adrenaline Hydrochloride and Acetylcholine Chloride on the beating signals was observed. Experiment results showed that the in vitro cardiac tissues and slices took on good beatings as well as the propagation. Adrenaline Hydrochloride and Acetylcholine Chloride respectively had exciting and relaxing action on signals’ amplitude, frequency, duration and even the signal conduction. In conclusion, the tissue-based sensing array technique is feasible to measure the beating signals of the in vitro cardiac tissues, and is quite advantageous to study the signal conduction and drugs screening.
出版日期: 2012-03-20
:  TP 212.3  
基金资助:

 国家自然科学基金资助项目（30970765, 60725102）.
通讯作者: 王平,男,教授,博导.     E-mail: cnpwang@zju.edu.cn
作者简介: 陈庆梅（1974—）,女,副教授,主要从事生物医学传感器研究. E-mail: zjucqm@zju.edu.cn
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引用本文:

陈庆梅, 李蓉, 肖丽丹, 刘清君, 王平. 心肌组织传感阵列在信号传导及药物分析中的应用[J]. J4, 2012, 46(2): 359-365.

CHEN Qing-mei, LI Rong, XIAO Li-dan, Liu Qing-jun, WANG Ping. Cardiac tissue-based sensing array for studying on signal
conduction and drugs analysis. J4, 2012, 46(2): 359-365.

链接本文:

http://www.zjujournals.com/eng/CN/10.3785/j.issn.1008-973X.2012.02.028    或    http://www.zjujournals.com/eng/CN/Y2012/V46/I2/359

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