Application and prospect of lipid peroxidation in the study of biochemical effects of environmental pollutants

doi:10.3785/j.issn.1008-9209.2020.10.281

Journal of Zhejiang University (Agriculture and Life Sciences)

2021, Vol. 47

Issue (5): 543-556 DOI: 10.3785/j.issn.1008-9209.2020.10.281

Reviews

Application and prospect of lipid peroxidation in the study of biochemical effects of environmental pollutants

Hongquan QIU(

),Xiaotie SHEN,Jing LIU,Daohui LIN,Yili HUANG(

)

Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China

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Abstract

Lipid is one of the four major biochemical molecules, and it plays important roles in many life processes. Lipid peroxidation (LPO) is commonly used to measure the effect of environmental pollutants or contamination factors on biochemistry processes. In this review, we summarized different kinds of pollutants or contamination factors that have been reported to induce LPO, including metals or metalloids, nanophase materials with different chemical properties, organic pollutants such as polycyclic aromatic hydrocarbons and pesticides, as well as environmental physical and chemical stress factors such as ozone, heat wave and radiation. Lipid peroxidation can occur in cells of different evolutionary classes of species, including bacteria, fungi, plants and animals. Most pollutants or contamination factors induce LPO through producing reactive oxidative species or inhibiting anti-oxidation systems. Therefore, this reaction is one of the important indicators of oxidative stresses caused by environmental pollutants. The LPO indexes are influenced by exposure time and doses, organism differences, and the balance between oxidation and anti-oxidation systems. In the future, we should be able to better understand the roles of lipids in the biochemical reaction to environmental pollution by using multi-omics technology and new measurements about lipid composition and membrane function.

Key words： lipid peroxidation environmental pollutant biochemical effect

Received: 28 October 2020 Published: 27 October 2021

CLC:

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Corresponding Authors: Yili HUANG E-mail: 3190103439@zju.edu.cn;yilihuang@zju.edu.cn

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Cite this article:

Hongquan QIU,Xiaotie SHEN,Jing LIU,Daohui LIN,Yili HUANG. Application and prospect of lipid peroxidation in the study of biochemical effects of environmental pollutants. Journal of Zhejiang University (Agriculture and Life Sciences), 2021, 47(5): 543-556.

URL:

http://www.zjujournals.com/agr/10.3785/j.issn.1008-9209.2020.10.281 OR http://www.zjujournals.com/agr/Y2021/V47/I5/543

脂质过氧化在环境污染物生化效应研究中的应用与展望

脂质是4大生物化学分子之一，参与了许多重要的生命活动过程。在研究环境污染物或污染因素的生化效应时，脂质过氧化程度是一项常用的检测指标。各种重金属或类金属，不同化学本质的纳米材料，多环芳烃、农药等有机污染物，以及臭氧、热浪、辐射等环境理化胁迫因素，都能引起脂质过氧化反应。脂质过氧化反应可以发生在不同进化阶层物种的细胞中，包括细菌、真菌、植物和动物等。大多数污染物或污染因素通过产生活性氧基团或抑制抗氧化系统的活性引起脂质过氧化反应，因此，该反应是环境污染物引起氧化应激效应的重要指标之一。脂质过氧化反应指标受实验设计中的污染物浓度、暴露时效、机体差异，特别是机体抗氧化系统的平衡作用等条件参数的影响。未来可以结合检测脂质组成和细胞膜功能的指标，以及利用现代组学的手段对参与脂质代谢的相关酶和基因进行研究，以期更全面地理解脂质在环境污染物生化效应中的作用。

关键词： 脂质, 过氧化, 环境污染物, 生化效应

Fig. 1 Whole process of lipid peroxidation (LPO)

Fig. 2 Number of LPO-relevant papers published in recent yearsNumber represents the number of papers in the field of environmental science that used lipid peroxidation (LPO) as a key word.

Table 1 Effects of different metals or metalloids on LPO indexes in different tested species

Table 2 Effects of different nanophase materials on LPO indexes in different tested species

有机污染物或化合物 Organic pollutant or compound

受试对象

Subject

脂质过氧化反应效应

LPO effect

名称 Name

浓度 Concentration

三氯苯酚

Trichlorophenol^[36]

5 μmol/L

黄瓜

Cucumis sativus

促进（MDA）

邻苯二甲酸二（2-乙基己基）酯

Di(2-ethylhexyl) phthalate^[37]

1.5 mg/L

秀丽隐杆线虫

Caenorhabditis elegans

促进（其他）

双酚S

Bisphenol S^[38]

0.1～1 000.0 μg/L

鲤鱼（巨噬细胞）

Cyprinus carpio (macrophage)

促进（MDA）

双酚F

Bisphenol F^[34]

100 ng/(g?d)

ICR小鼠（肝）

ICR mice (liver)

促进（MDA）

磷酸三（1，3-二氯异丙基）酯

Tris (1, 3-dichloro-2-propyl) phosphate^[39]

0.1～1 000.0 μg/L

秀丽隐杆线虫

Caenorhabditis elegans

促进（4-HNE）

十溴联苯醚

Deca-brominated diphenyl ether^[40]

10～500 μg/L

水稻

Oryza sativa

促进（MDA）

苯并芘

Benzopyrene^[32]

0.33、1.00 μmol/L

虹鳟

Oncorhynchus mykiss

促进（MDA）

菲

Phenanthrene^[33]

0.5～50.0 μg/kg

SD大鼠

SD rats

促进（MDA）

β-氯氰菊酯

β-cypermethrin^[41]

0.01、0.1 μg/L

斑马鱼

Danio rerio

促进/抑制（MDA）

草甘膦

Glyphosate^[41]

52.08、104.15 mg/L

鲤鱼（鳃）

Cyprinus carpio (gill)

促进（MDA）

土霉素

Oxytetracycline^[36]

50 μmol/L

黄瓜

Cucumis sativus

促进（MDA）

恩诺沙星

Enrofloxacin^[4]

1～100 mg/L

微藻

Microalgae

促进/抑制（MDA）

嘧菌酯

Azoxystrobin^[42]

2.5、5.0 mg/L

蛋白核小球藻

Chlorella pyrenoidosa

促进（MDA）

丙硫菌唑

Prothioconazole^[43]

0.037 5～0.150 0 mg/L

斑马鱼（胚胎）

Danio rerio (embryo)

促进（MDA）

顺铂

Cisplatin^[44]

0.1～100.0 ng/L

沙蚕

Nereis diversicolor

促进（MDA＋4-HNE）

双氯芬酸

Diclofenac^[20]

770 mg/L

大斑南乳鱼

Galaxias maculatus

抑制/促进（MDA）

对乙酰氨基酚

Paracetamol^[28]

400 mg/kg

大麦（根、叶）

Hordeum vulgare (root, leaf)

无显著影响（MDA）

微囊藻毒素

Microcystic toxins^[45]

3～30 μg/L

斑马鱼（肝）

Danio rerio (liver)

促进（MDA）

柠檬酸/乙二胺四乙酸（＋铜）

Citric acid/EDTA (＋ copper)^[17]

0.157 mmol/L

(＋0.157 mmol/L Cu)

黑麦草

Lolium perenne

促进/抑制（MDA）

Table 3 Effects of different organic pollutants on LPO indexes in different tested species

Table 4 Effects of environmental physical and chemical stress factors on LPO indexes in different tested species

Fig. 3 Schematic illustration of the mechanism and influencing factors of LPO caused by environmental pollutants or contamination factors


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