细胞程序性死亡与脊椎动物胚胎发育综述

doi:10.3785/j.issn.1008-9209.2022.03.101

浙江大学学报（农业与生命科学版）

2023, Vol. 49

Issue (2): 213-228 DOI: 10.3785/j.issn.1008-9209.2022.03.101

综述

细胞程序性死亡与脊椎动物胚胎发育综述

栾静云(

),徐鹏飞(

)

浙江大学医学院，浙江杭州 310058

Review on programmed cell death and vertebrate embryonic development

Jingyun LUAN(

),Pengfei XU(

)

College of Medicine, Zhejiang University, Hangzhou 310058, Zhejiang, China

全文: PDF(2010 KB) HTML

摘要：

脊椎动物胚胎发育是细胞通过分裂、增殖、分化、迁移及细胞程序性死亡等一系列行为进行自我组织的复杂过程。其中，细胞程序性死亡存在于胚胎发育的各个阶段，对胚胎的发育具有重要调控作用，是器官生成、形态建立和组织稳态维持等发育相关事件所必需的。本文对近年来细胞程序性死亡调控脊椎动物胚胎发育过程的相关研究进展进行了综述，包括早期胚胎发育过程中细胞程序性死亡的生物学功能、调节机制及死亡细胞的清除方式等，重点关注了细胞程序性死亡与脊椎动物胚胎发育过程之间的密切联系。本综述将为更全面地了解细胞程序性死亡在脊椎动物胚胎发育过程中的作用提供借鉴与帮助，并有望为将来通过人为调控细胞程序性死亡来提高胚胎发育质量提供一定的思路。

关键词： 细胞程序性死亡; 脊椎动物; 胚胎发育

Abstract:

Vertebrate embryonic development is a complex process in which cells self-organize into a completely formed organism via cell behaviors such as division, proliferation, differentiation, migration, and programmed cell death (PCD). Among these cell behaviors, PCD exists in all stages of embryonic development, playing important roles in organogenesis, morphogenesis, and maintenance of tissue homeostasis. In this review, we summarized recent research progress on the regulation of vertebrate embryonic development by PCD, including the biological function and regulatory mechanism of PCD and clearance of dead cells during early embryonic development, focusing on the close link between PCD and embryonic developmental processes. We hope this review will help build a more comprehensive understanding of the roles of PCD in vertebrate embryonic development, and provide insights into how PCD is manipulated to improve the quality of embryonic development in the future.

Key words: programmed cell death vertebrate embryonic development

收稿日期: 2022-03-10 出版日期: 2023-04-27

CLC:

Q593.4

基金资助: 国家重点研发计划项目(2018YFC1003203)

通讯作者: 徐鹏飞 E-mail: 21918064@zju.edu.cn;pengfei_xu@zju.edu.cn

作者简介: 栾静云（https://orcid.org/0000-0002-7043-0992），E-mail：21918064@zju.edu.cn

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引用本文:

栾静云,徐鹏飞. 细胞程序性死亡与脊椎动物胚胎发育综述[J]. 浙江大学学报（农业与生命科学版）, 2023, 49(2): 213-228.

Jingyun LUAN,Pengfei XU. Review on programmed cell death and vertebrate embryonic development. Journal of Zhejiang University (Agriculture and Life Sciences), 2023, 49(2): 213-228.

链接本文:

https://www.zjujournals.com/agr/CN/10.3785/j.issn.1008-9209.2022.03.101 或 https://www.zjujournals.com/agr/CN/Y2023/V49/I2/213

表1 细胞死亡类型及特征

图1 小鼠胚胎发育过程中细胞程序性死亡的生物学功能

图2 细胞程序性死亡调控组织和器官正确生成A.细胞程序性死亡调控正确形态发生素浓度梯度的建立；B.细胞程序性死亡参与组织和器官生成；C.细胞程序性死亡参与临时性结构或器官的消除；D.细胞程序性死亡调控机体内细胞总数。

图3 早期死亡细胞的消除方式A.上皮细胞通过挤压消除死亡细胞；B1～B2.上皮细胞和神经嵴细胞识别并吞噬死亡细胞（B1.上皮细胞通过吞噬杯及“上皮臂”诱导死亡细胞的快速分散和摄取，这种机械性的“负载共享”机制使多个上皮细胞能够远程协同摄取死亡细胞；B2.神经嵴细胞能够对神经管周围的垂死细胞做出快速反应，随后从其节段受限的路径迁移至死亡细胞并吞噬死亡碎片）。

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