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浙江大学学报（农业与生命科学版）
浙江大学学报（农业与生命科学版）  2023, Vol. 49 Issue (5): 591-606    DOI: 10.3785/j.issn.1008-9209.2023.05.101
青年科学家论坛     
植物雷帕霉素靶蛋白激酶研究进展
陈文臻1,2(),刘佳琦1,都浩1
1.浙江大学农业与生物技术学院现代种业研究所，浙江 杭州 310058
2.浙江大学海南研究院，海南 三亚 572025
Research progresses on target of rapamycin kinase in plants
Wenzhen CHEN1,2(),Jiaqi LIU1,Hao DU1
1.Advanced Seed Institute, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, Zhejiang, China
2.Hainan Institute of Zhejiang University, Sanya 572025, Hainan, China
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摘要：

植物雷帕霉素靶蛋白（target of rapamycin, TOR）作为信号和代谢调节中枢，通过磷酸化修饰整合营养、能量和环境信号，感知植物体内能量变化，调节植物生长发育和环境适应过程。在本文中，我们回顾了TOR的发现历程，总结了以往和近期植物TOR的信号通路研究进展（包括新发现的部分上游效应因子和下游调控路径），TOR在植物胚胎发生、分生组织形成、养分利用、开花和衰老等不同生长发育阶段或代谢过程中的重要作用，以及响应非生物胁迫和生物胁迫的生物学机制，还展望了TOR激酶在未来的研究热点方向及其在农业生产中的应用。
关键词： 雷帕霉素靶蛋白;  蛋白激酶;  信号通路;  生长发育;  环境适应    
Abstract:

In plants, target of rapamycin (TOR) functions as a pivotal signaling and metabolic hub, integrating nutrient availability, energy status, and environmental cues through phosphorylation. This regulatory mechanism plays a crucial role in governing plant growth, development, and environmental adaptation. In this paper, we provide a comprehensive review of the discovery and characterization of TOR in plants. We summarize previous and recent studies on the signaling pathway of plant TOR, highlighting the identification of upstream effect factors and downstream substrates. Additionally, we discuss the diverse roles of TOR in plant embryogenesis, meristem formation, nutrient utilization, flowering, senescence, and responses to both abiotic and biotic stresses. Furthermore, we explore the potential research prospects for TOR kinase and its application in agriculture.
Key words: target of rapamycin    protein kinase    signaling pathway    growth and development    environmental adaptation
收稿日期: 2023-05-10 出版日期: 2023-11-03
CLC:  S-3  
基金资助: 海南省自然科学基金联合项目(320LH031);浙江省自然科学基金项目(LY21C020003);中央高校基本科研业务费专项资金项目(K20200168)
通讯作者: 都浩     E-mail: 1870357504@qq.com
作者简介: 陈文臻（https://orcid.org/0009-0002-0242-9508），E-mail：1870357504@qq.com|都浩，博士，浙江大学农业与生物技术学院研究员，博士生导师。2003—2013 年在华中农业大学生命科学技术学院先后获得理学学士学位、生物化学与分子生物学博士学位，其间主要从事水稻发育与逆境生物学研究。2015—2019 年在哈佛大学从事拟南芥能量调控机制和系统生物学研究。2019 年底加入浙江大学农业与生物技术学院现代种业研究所，主要从事植物合成生物技术平台构建、作物能量调控与碳氮平衡机制方面的研究。至今，在Nature、MolecularPlant、Plant Biotechnology Journal、New Phytologist、The Plant Journal、Plant Physiology、Journalof Integrative Plant Biology、Journal of Experimental Botany、Theoretical and Applied Genetics 等国际主流期刊上发表研究论文28 篇。获得国家授权发明专利4 项。发表的论文总被引3 000 多次，h 指数18。（https://orcid.org/0000-0003-2248-0271），E-mail：du_hao@zju.edu.cn
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引用本文:

陈文臻,刘佳琦,都浩. 植物雷帕霉素靶蛋白激酶研究进展[J]. 浙江大学学报（农业与生命科学版）, 2023, 49(5): 591-606.

Wenzhen CHEN,Jiaqi LIU,Hao DU. Research progresses on target of rapamycin kinase in plants. Journal of Zhejiang University (Agriculture and Life Sciences), 2023, 49(5): 591-606.

链接本文:

https://www.zjujournals.com/agr/CN/10.3785/j.issn.1008-9209.2023.05.101    或    https://www.zjujournals.com/agr/CN/Y2023/V49/I5/591

图1  动植物TOR激酶及其复合体亚基结构实线箭头代表蛋白结合位置，T形箭头代表抑制作用。
图2  TOR在植物发育中的核心调控作用
图3  植物中TOR调控网络示意图实线箭头代表直接激活作用，虚线箭头代表间接激活作用，T形箭头代表抑制作用。
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