| Biotechnology |
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| Epigenetic regulation of adipocyte differentiation and adipogenesis |
| Hong-xing Li, Lei Xiao, Cheng Wang, Jia-li Gao, Yong-gong Zhai |
| Key Laboratory for Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing 100875, China; Reproductive Medicine Research Center, the First Hospital of Lanzhou University, Lanzhou 730000, China; Beijing Key Laboratory of Engineered Drug and Biotechnology, College of Life Sciences, Beijing Normal University, Beijing 100875, China; Biomedicine Research Institute, College of Life Sciences, Beijing Normal University, Beijing 100875, China; Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China |
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Abstract It is generally agreed that adipocytes originate from mesenchymal stem cells in what can be divided into two processes: determination and differentiation. In the past decade, many factors associated with epigenetic signals have been proved to be pivotal for the appropriate timing of adipogenesis progression. A large number of coregulators at critical gene promoters set up specific patterns of DNA methylation, histone acetylation and methylation, and nucleosome rearrangement, that act as an epigenetic code to modulate the correct progress of adipocyte differentiation and adipogenesis during adipogenesis. In this review, we focus on the functions and roles of epigenetic processes in preadipocyte differentiation and adipogenesis.
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Received: 11 December 2009
Published: 05 October 2010
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