| Biomedicine |
|
|
|
|
| Association of p53 codon 72 polymorphism with liver metastases of colorectal cancers positive for p53 overexpression |
| Zhong-zheng ZHU, Bing LIU, Ai-zhong WANG, Hang-ruo JIA, Xia-xiang JIN, Xiang-lei HE, Li-fang HOU, Guan-shan ZHU |
| Department of Pathology, No. 113 Hospital of People’s Liberation Army, Ningbo 315040, China; Department of Urology, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China; Department of Pathology, Lihuili Hospital, Ningbo 315041, China; Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Innovation Center China, AstraZeneca Global R & D, Shanghai 201203, China |
|
|
|
Abstract Objective: To evaluate the association between p53 codon 72 polymorphism (R72P) and the risk of colorectal liver metastases. Methods: The p53 R72P genotype was identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in 78 consecutive colorectal cancer patients with liver metastases and 214 age- and sex-matched cases with nonmetastatic colorectal cancer. Results: The R allele of the p53 R72P polymorphism was more frequently found in metastatic cases than in nonmetastatic cases (P=0.075). Carriers of the 72R allele had a 2.25-fold (95% CI (confidence interval)=1.05~4.83) increased risk of liver metastases. On the stratification analysis, 72R-carrying genotype conferred a 3.46-fold (95% CI=1.02~11.72) and a 1.05-fold (95% CI=0.36~3.08) increased risk of liver metastases for p53 overexpression-positive and negative colorectal cancers, respectively. Conclusion: These results demonstrate for the first time that the 72R allele of the p53 polymorphism has an increased risk for liver metastases in colorectal cancers positive for p53 overexpression.
|
|
Received: 27 March 2008
|
|
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
| |
Shared |
|
|
|
|
| |
Discussed |
|
|
|
|
