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| Effects of yeast products on the intestinal morphology, barrier function, cytokine expression, and antioxidant system of weaned piglets |
| Huan-sheng Yang, Fei Wu, Li-na Long, Tie-jun Li, Xia Xiong, Peng Liao, Hong-nan Liu, Yu-long Yin |
| Observation and Experiment Station of Animal Nutrition and Feed Science in South-Central China, Ministry of Agriculture; Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production; Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China; School of Life Sciences, Hunan Normal University, Changsha 410006, China; Fujian Aonong Bio-Technology Co., Ltd., Xiamen 361008, China; National Research Center of Engineering Technology for Utilization of Botanical Functional Ingredients from Botanicals, Provincial Co-Innovation Center for Utilization of Botanical Function Ingredients, Hunan Agricultural University, Changsha 410128, China |
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Abstract The goal of this study was to evaluate the effects of a mixture of yeast culture, cell wall hydrolysates, and yeast extracts (collectively “yeast products,” YP) on the performance, intestinal physiology, and health of weaned piglets. A total of 90 piglets weaned at 21 d of age were blocked by body weight, sex, and litter and randomly assigned to one of three treatments for a 14-d feeding experiment, including (1) a basal diet (control), (2) 1.2 g/kg of YP, and (3) 20 mg/kg of colistin sulfate (CSE). No statistically significant differences were observed in average daily feed intake, average daily weight gain, or gain-to-feed ratio among CSE, YP, and control piglets. Increased prevalence of diarrhea was observed among piglets fed the YP diet, whereas diarrhea was less prevalent among those fed CSE. Duodenal and jejunal villus height and duodenal crypt depth were greater in the control group than they were in the YP or CSE groups. Intraepithelial lymphocytes (IEL) in the duodenal and jejunal villi were enhanced by YP, whereas IEL in the ileal villi were reduced in weaned piglets fed YP. Secretion of jejunal and ileal interleukin-10 (IL-10) was higher and intestinal and serum antioxidant indexes were affected by YP and CSE. In YP- and CSE-supplemented animals, serum D-lactate concentration and diamine oxidase (DAO) activity were both increased, and intestinal mRNA expressions of occludin and ZO-1 were reduced as compared to the control animals. In conclusion, YP supplementation in the diets of weaned piglets appears to increase the incidence of diarrhea and has adverse effects on intestinal morphology and barrier function.
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Received: 13 August 2015
Published: 02 October 2016
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Cite this article:
Huan-sheng Yang, Fei Wu, Li-na Long, Tie-jun Li, Xia Xiong, Peng Liao, Hong-nan Liu, Yu-long Yin. Effects of yeast products on the intestinal morphology, barrier function, cytokine expression, and antioxidant system of weaned piglets. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2016, 17(10): 752-762.
URL:
http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1500192 OR http://www.zjujournals.com/xueshu/zjus-b/Y2016/V17/I10/752
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