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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2016, Vol. 17 Issue (12): 965-974    DOI: 10.1631/jzus.B1600078
Articles     
Effects of soybean isoflavone on intestinal antioxidant capacity and cytokines in young piglets fed oxidized fish oil
Lin Huang, Xian-yong Ma, Zong-yong Jiang, You-jun Hu, Chun-tian Zheng, Xue-fen Yang, Li Wang, Kai-guo Gao
Institute of Animal Science, Guangdong Academy of Agricultural Sciences, the Key Laboratory of Animal Nutrition and Feed Science (South China) of Ministry of Agriculture, State Key Laboratory of Livestock and Poultry Breeding, Guangdong Public Laboratory of Animal Breeding and Nutrition, Guangdong Key Laboratory of Animal Breeding and Nutrition, Guangzhou 510640, China
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Abstract  To investigate the effect of glycitein, a synthetic soybean isoflavone (ISF), on the intestinal antioxidant capacity, morphology, and cytokine content in young piglets fed oxidized fish oil, 72 4-d-old male piglets were assigned to three treatments. The control group was fed a basal diet containing fresh fish oil, and the other two groups received the same diet except for the substitution with the same dosage of oxidized fish oil alone or with ISF (oxidized fish oil plus ISF). After 21 d of feeding, supplementation of oxidized fish oil increased the levels of malondialdehyde (MDA), oxidized glutathione (GSSG), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), interleukin-2 (IL-2), nuclear factor κ B (NF-κB), inducible nitric oxide synthase (iNOS), NO, and Caspase-3 in jejunal mucosa, and decreased the villous height in duodenum and the levels of secretory immunoglobulin A (sIgA) and IL-4 in the jejunal mucosa compared with supplementation with fresh oil. The addition of oxidized fish oil plus ISF partially alleviated this negative effect. The addition of oxidized fish oil plus ISF increased the villous height and levels of sIgA and IL-4 in jejunal mucosa, but decreased the levels of IL-1β and IL-2 in jejunal mucosa (P<0.05) compared with oxidized fish oil. Collectively, these results show that dietary supplementation of ISF could partly alleviate the negative effect of oxidized fish oil by improving the intestinal morphology as well as the antioxidant capacity and immune function in young piglets.

Key words： Young piglets      Oxidized fish oil      Growth performance      Soybean isoflavone      Antioxidant capacity     
Received: 21 February 2016      Published: 05 December 2016
CLC:  S828.5  
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Lin Huang
Xian-yong Ma
Zong-yong Jiang
You-jun Hu
Chun-tian Zheng
Xue-fen Yang
Li Wang
Kai-guo Gao
Cite this article:

Lin Huang, Xian-yong Ma, Zong-yong Jiang, You-jun Hu, Chun-tian Zheng, Xue-fen Yang, Li Wang, Kai-guo Gao. Effects of soybean isoflavone on intestinal antioxidant capacity and cytokines in young piglets fed oxidized fish oil. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2016, 17(12): 965-974.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1600078     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2016/V17/I12/965

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