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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2007, Vol. 8 Issue (1): 39-44    DOI: 10.1631/jzus.2007.B0039
Bioengineering     
FoxO4 is the main forkhead transcriptional factor localized in the gastrointestinal tracts of pigs
ZHOU Zhen-qi, WANG Tian, PAN Ling-mei, HUANG Rui-hua, SHI Fang-xiong
College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China
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Abstract  Forkhead box (Fox) proteins play critical roles in the regulation of differentiation, proliferation, immunity and aging of cells. Most studies on Fox proteins are limited to cultured cells and rodent. The aim of the current study is to detect by immunohistrochemistry whether FoxO1, FoxO3a and FoxO4 proteins are localized in the stomach and intestine of the pig. The results showed that FoxO4 exists in the mucosa in all parts of the stomach and intestine; FoxO3a exists mainly in the lamina propria and muscularis of some parts. However, FoxO1 is not detectable in all parts of the stomach and intestine. Collectively, the results of the present study indicate that there exists a distinct expression pattern of Fox proteins, and that FoxO4 is a primary forkhead transcriptional factor localized in the gastrointestinal tracts of the pig.

Key words： Forkhead      FoxO      Gastrointestinal tract      Immunohistochemistry      Swine     
Received: 14 April 2006     
CLC:  S828  
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ZHOU Zhen-qi
WANG Tian
PAN Ling-mei
HUANG Rui-hua
SHI Fang-xiong
Cite this article:

ZHOU Zhen-qi, WANG Tian, PAN Ling-mei, HUANG Rui-hua, SHI Fang-xiong. FoxO4 is the main forkhead transcriptional factor localized in the gastrointestinal tracts of pigs. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2007, 8(1): 39-44.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.2007.B0039     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2007/V8/I1/39

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