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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2014, Vol. 15 Issue (8): 681-691    DOI: 10.1631/jzus.B1400120
Review     
Optimal pig donor selection in islet xenotransplantation: current status and future perspectives
Hai-tao Zhu, Liang Yu, Yi Lyu, Bo Wang
Department of Hepatobiliary Surgery, the First Affiliated Hospital, Medical College, Xi'an Jiaotong University, Xi'an 710061, China
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Abstract  Islet transplantation is an attractive treatment of type 1 diabetes mellitus. Xenotransplantation, using the pig as a donor, offers the possibility of an unlimited supply of islet grafts. Published studies demonstrated that pig islets could function in diabetic primates for a long time (>6 months). However, pig-islet xenotransplantation must overcome the selection of an optimal pig donor to obtain an adequate supply of islets with high-quality, to reduce xeno-antigenicity of islet and prolong xenograft survival, and to translate experimental findings into clinical application. This review discusses the suitable pig donor for islet xenotransplantation in terms of pig age, strain, structure/function of islet, and genetically modified pig.

Key words： Islet      Pig      Xenotransplantation      Donor     
Received: 28 April 2014      Published: 05 August 2014
CLC:  R617  
  R335+.6  
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Hai-tao Zhu, Liang Yu, Yi Lyu, Bo Wang. Optimal pig donor selection in islet xenotransplantation: current status and future perspectives. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2014, 15(8): 681-691.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1400120     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2014/V15/I8/681

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