Please wait a minute...
ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2014, Vol. 15 Issue (5): 409-411    DOI: 10.1631/jzus.B1400113
Editorial     
Transcription: the epicenter of gene expression
Jiannan Guo
Department of Biochemistry, University of Iowa, Iowa City, IA 52242, USA
Download:     PDF (0 KB)     
Export: BibTeX | EndNote (RIS)      

Abstract  The complexity of a living organism is not driven by gene number but gene regulation. Controlling which genes to express and to what extent dictates the subsequent cell identity. Transcription, the critical initial stage in gene expression, is regulated delicately to maintain the cell status. Recent developments in the genomic approaches provided unparalleled coverage of the study of transcription. Still, basic molecular biology and biochemistry are providing mechanistic insights into how the regulation is achieved. In this feature 鈥淩egulation of transcription: mechanisms and biological functions鈥? the latest advances in epigenetics, mRNA processing, RNA quality control, and human immunodeficiency virus (HIV) transactivation are discussed.

Key words： Gene expression      Transcription      DNA      RNA     
Received: 16 March 2014      Published: 05 May 2014
Service
E-mail this article
Add to my bookshelf
Add to citation manager
E-mail Alert
RSS
Articles by authors
Jiannan Guo
Cite this article:

Jiannan Guo. Transcription: the epicenter of gene expression. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2014, 15(5): 409-411.

URL:

http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1400113     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2014/V15/I5/409

[1] Meng-wen Zhang, Kenji Fujiwara, Xu Che, Shu Zheng, Lei Zheng. DNA methylation in the tumor microenvironment[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2017, 18(5): 365-372.
[2] Shi-chong Liao, Jin-xin Li, Li Yu, Sheng-rong Sun. Protein tyrosine phosphatase 1B expression contributes to the development of breast cancer[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2017, 18(4): 334-342.
[3] Shi-yuan Hong. DNA damage response is hijacked by human papillomaviruses to complete their life cycle[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2017, 18(3): 215-232.
[4] Ye-li Yao, Qi-fang Tian, Bei Cheng, Yi-fan Cheng, Jing Ye, Wei-guo Lu. Human papillomavirus (HPV) E6/E7 mRNA detection in cervical exfoliated cells: a potential triage for HPV-positive women[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2017, 18(3): 256-262.
[5] Ning Zhang, Wei-hua Lou, Xue-bin Zhang, Jia-ning Fu, Yun-yan Chen, Zhi-guo Zhuang, Jian-hua Lin. Vascular complications following prophylactic balloon occlusion of the internal iliac arteries resolved by successful interventional thrombolysis in a patient with morbidly adherent placenta[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2017, 18(3): 272-276.
[6] Zhong-dong Wang, Fan-yong Qu, Yuan-yuan Chen, Zhang-shen Ran, Hai-yan Liu, Hai-dong Zhang. Involvement of microRNA-718, a new regulator of EGR3, in regulation of malignant phenotype of HCC cells[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2017, 18(1): 27-36.
[7] Roxana Karbaschi, Forouzan Sadeghimahalli, Homeira Zardooz. Maternal high-fat diet inversely affects insulin sensitivity in dams and young adult male rat offspring[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2016, 17(9): 728-732.
[8] Cai-fang Wen, Li-xin Xi, Shan Zhao, Zhong-xiang Hao, Lu Luo, Hong Liao, Zhen-rong Chen, Rong She, Guo-quan Han, San-jie Cao, Rui Wu, Qi-gui Yan, Rong Hou. Chryseobacterium chengduensis sp. nov. isolated from the air of captive giant panda enclosures in Chengdu, China[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2016, 17(8): 610-618.
[9] Qing-ping Tang, Qin Shen, Li-xiang Wu, Xiang-ling Feng, Hui Liu, Bei Wu, Xiao-song Huang, Gai-qing Wang, Zhong-hao Li, Zun-jing Liu. STAT3 signal that mediates the neural plasticity is involved in willed-movement training in focal ischemic rats[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2016, 17(7): 493-502.
[10] Di Chen, Xiao-xuan Xin, Hao-cheng Qian, Zhang-yin Yu, Li-rong Shen. Evaluation of the major royal jelly proteins as an alternative to fetal bovine serum in culturing human cell lines[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2016, 17(6): 476-483.
[11] Ri-sheng Que, Cheng Lin, Guo-ping Ding, Zheng-rong Wu, Li-ping Cao. Increasing the immune activity of exosomes: the effect of miRNA-depleted exosome proteins on activating dendritic cell/cytokine-induced killer cells against pancreatic cancer[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2016, 17(5): 352-360.
[12] Xiao-yan Cui, Ying-ying Li, Ran-ran Liu, Gui-ping Zhao, Mai-qing Zheng, Qing-he Li, Jie Wen. Follicle-stimulating hormone increases the intramuscular fat content and expression of lipid biosynthesis genes in chicken breast muscle[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2016, 17(4): 303-310.
[13] Shao-hua Hu, Shu-xing Yuan, Hai Qu, Tao Jiang, Ya-jun Zhou, Ming-xi Wang, De-song Ming. Antibiotic resistance mechanisms of Myroides sp.[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2016, 17(3): 188-199.
[14] Bin Xu, Yao-yao Li, Jun Ma, Fu-xing Pei. Roles of microRNA and signaling pathway in osteoarthritis pathogenesis[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2016, 17(3): 200-208.
[15] Hai-ping Lu, Wei-qin Pang, Wen-xu Li, Yuan-yuan Tan, Qing Wang, Hai-Jun Zhao, Qing-Yao Shu. Tissue-specific expression, developmentally and spatially regulated alternative splicing, and protein subcellular localization of OsLpa rice[J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2016, 17(2): 100-109.