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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2016, Vol. 17 Issue (3): 188-199    DOI: 10.1631/jzus.B1500068
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Antibiotic resistance mechanisms of Myroides sp.
Shao-hua Hu, Shu-xing Yuan, Hai Qu, Tao Jiang, Ya-jun Zhou, Ming-xi Wang, De-song Ming
Yun Leung Laboratory for Molecular Diagnostics, School of Biomedical Sciences and Institute of Molecular Medicine, Huaqiao University / Engineering Research Center of Molecular Medicine, Ministry of Education, Xiamen 361021, China; Department of Neurosurgery, Linyi People's Hospital, Linyi 276000, China; Linyi Health School of Shandong Province, Linyi 276000, China; Institute of Nanomedicine, Department of Medical Laboratory, Weifang Medical College, Weifang 261053, China; Department of Clinical Laboratory, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou 362000, China
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Abstract  Bacteria of the genus Myroides (Myroides spp.) are rare opportunistic pathogens. Myroides sp. infections have been reported mainly in China. Myroides sp. is highly resistant to most available antibiotics, but the resistance mechanisms are not fully elucidated. Current strain identification methods based on biochemical traits are unable to identify strains accurately at the species level. While 16S ribosomal RNA (rRNA) gene sequencing can accurately achieve this, it fails to give information on the status and mechanisms of antibiotic resistance, because the 16S rRNA sequence contains no information on resistance genes, resistance islands or enzymes. We hypothesized that obtaining the whole genome sequence of Myroides sp., using next generation sequencing methods, would help to clarify the mechanisms of pathogenesis and antibiotic resistance, and guide antibiotic selection to treat Myroides sp. infections. As Myroides sp. can survive in hospitals and the environment, there is a risk of nosocomial infections and pandemics. For better management of Myroides sp. infections, it is imperative to apply next generation sequencing technologies to clarify the antibiotic resistance mechanisms in these bacteria.

Key words： Myroides sp.      Antibiotic resistance      Identification methods      16S ribosomal RNA gene sequencing      Next generation sequencing     
Received: 19 March 2015      Published: 07 March 2016
CLC:  R378  
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Shao-hua Hu
Shu-xing Yuan
Hai Qu
Tao Jiang
Ya-jun Zhou
Ming-xi Wang
De-song Ming
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Shao-hua Hu, Shu-xing Yuan, Hai Qu, Tao Jiang, Ya-jun Zhou, Ming-xi Wang, De-song Ming. Antibiotic resistance mechanisms of Myroides sp.. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2016, 17(3): 188-199.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1500068     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2016/V17/I3/188

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