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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2016, Vol. 17 Issue (3): 200-208    DOI: 10.1631/jzus.B1500267
Reviews     
Roles of microRNA and signaling pathway in osteoarthritis pathogenesis
Bin Xu, Yao-yao Li, Jun Ma, Fu-xing Pei
Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, China; Zhongnan Hospital, Wuhan University, Wuhan 430071, China
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Abstract  Osteoarthritis (OA) is a common chronic degenerative joint disease, with complicated pathogenic factors and undefined pathogenesis. Various signaling pathways play important roles in OA pathogenesis, including genetic expression, matrix synthesis and degradation, cell proliferation, differentiation, apoptosis, and so on. MicroRNA (miRNA) is a class of non-coding RNA in Eukaryon, regulating genetic expression on the post-transcriptional level. A great number of miRNAs are involved in the development of OA, and are closely associated with different signaling pathways. This article reviews the roles of miRNAs and signaling pathways in OA, looking toward having a better understanding of its pathogenesis mechanisms and providing new therapeutic targets for its treatment.

Key words： MicroRNA      Signaling pathway      Osteoarthritis      Pathogenesis     
Received: 04 November 2015      Published: 07 March 2016
CLC:  R684.3  
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Bin Xu
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Fu-xing Pei
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Bin Xu, Yao-yao Li, Jun Ma, Fu-xing Pei. Roles of microRNA and signaling pathway in osteoarthritis pathogenesis. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2016, 17(3): 200-208.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1500267     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2016/V17/I3/200

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