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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2012, Vol. 13 Issue (8): 603-608    DOI: 10.1631/jzus.B1201006
Perspective     
Global impact of RNA splicing on transcriptome remodeling in the heart
Chen Gao, Yibin Wang
Molecular Biology Institute, University of California, Los Angeles, California 90095, USA
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Abstract  In the eukaryotic transcriptome, both the numbers of genes and different RNA species produced by each gene contribute to the overall complexity. These RNA species are generated by the utilization of different transcriptional initiation or termination sites, or more commonly, from different messenger RNA (mRNA) splicing events. Among the 30000+ genes in human genome, it is estimated that more than 95% of them can generate more than one gene product via alternative RNA splicing. The protein products generated from different RNA splicing variants can have different intracellular localization, activity, or tissue-distribution. Therefore, alternative RNA splicing is an important molecular process that contributes to the overall complexity of the genome and the functional specificity and diversity among different cell types. In this review, we will discuss current efforts to unravel the full complexity of the cardiac transcriptome using a deep-sequencing approach, and highlight the potential of this technology to uncover the global impact of RNA splicing on the transcriptome during development and diseases of the heart.

Key words： Alternative RNA splicing      Transcriptome      Gene regulation      Heart      RNA-seq     
Received: 20 June 2012      Published: 01 August 2012
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Chen Gao, Yibin Wang. Global impact of RNA splicing on transcriptome remodeling in the heart. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2012, 13(8): 603-608.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1201006     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2012/V13/I8/603

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