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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2008, Vol. 9 Issue (8): 649-655    DOI: 10.1631/jzus.B0820003
Biomedicine     
Accuracy of a combined score of zygote and embryo morphology for selecting the best embryos for IVF
Yu-li QIAN, Ying-hui YE, Chen-ming XU, Fan JIN, He-feng HUANG
Department of Reproductive Endocrinology, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
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Abstract  Objective: To evaluate the accuracy of a scoring system combining zygote and embryo morphology in predicting the outcome of in vitro fertilization (IVF) treatment. Methods: In a study group, 117 consecutive IVF or intracytoplasmic sperm injection (ICSI) cycles with embryo transfer were carried out and 312 embryos were scored using a combined scoring system (CSS) of zygote and embryo morphology before transplantation. In a control group, a total of 420 IVF or ICSI cycles were carried out and 1176 embryos were scored using a cumulative embryo score (CES). The effects of the combined scoring system on the embryo implantation rate and pregnancy rate per cycle were analyzed. Results: Using the combined scoring system, the embryo implantation rate (27.6%) and the clinical pregnancy rate (48.7%) were significantly higher than those in the control group (20.8% and 38.6%, respectively). Also, the implantation rate of embryos scoring ≥70 (38.5%: 82 sacs/213 embryos) was significantly higher (P<0.001) than that of embryos scoring <70 (4%: 4 sacs/99 embryos). The pregnancy rate of patients with embryos scoring ≥70 using the combined scoring system (66.7%) was significantly higher (P<0.001) than that of patients with embryos scoring ≥20 using the cumulative embryo score (59.0%). Conclusion: The results suggest that selecting embryos with a high score (≥70) using the combined scoring system could increase the implantation rate and pregnancy rate, and that using a scoring system combining assessments of human zygotes and pre-implantation embryos might predict IVF outcomes more accurately than using a cumulative embryo score.

Key words： Embryo score      Combined scoring system (CSS)      Implantation      In vitro fertilization (IVF)      Pregnancy     
Received: 04 January 2008     
CLC:  R715  
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Yu-li QIAN
Ying-hui YE
Chen-ming XU
Fan JIN
He-feng HUANG
Cite this article:

Yu-li QIAN, Ying-hui YE, Chen-ming XU, Fan JIN, He-feng HUANG. Accuracy of a combined score of zygote and embryo morphology for selecting the best embryos for IVF. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2008, 9(8): 649-655.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B0820003     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2008/V9/I8/649

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