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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2011, Vol. 12 Issue (10): 787-795    DOI: 10.1631/jzus.B1100166
    
Clinical outcomes of fertility-sparing treatments in young patients with epithelial ovarian carcinoma
Jun Hu, Li-rong Zhu, Zhi-qing Liang, Yuan-guang Meng, Hong-yan Guo, Peng-peng Qu, Cai-ling Ma, Cong-jian Xu, Bi-bo Yuan
Department of Gynecology, Peking University First Hospital, Beijing 100034, China, Department of Gynecology, Southwest Hospital of Third Military Medical University, Chongqing 400038, China, Department of Gynecology, Chinese PLA General Hospital & Chinese PLA Postgraduate Medical School, Beijing 100853, China, Department of Gynecology, Peking University Third Hospital, Beijing 100191, China, Tianjin Central Obstetrics and Gynecological Hospital, Tianjin 300052, China, Department of Gynecology, Xinjiang Medical University First Teaching Hospital, Urumqi 830054, China, Shanghai Red House Hospital of Obstetrics and Gynecology, Shanghai 200011, China, Department of Gynecology, Tianjin Medical University General Hospital, Tianjin 300052, China
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Abstract  Objective: To assess the clinical outcomes of fertility-sparing treatments in young patients with epithelial ovarian carcinoma (EOC). Methods: A retrospective study of young EOC inpatients (≤40 years old) was performed during January 1994 and December 2010 in eight institutions. Results: Data were analyzed from 94 patients treated with fertility-sparing surgery with a median follow-up time of 58.7 months. As histologic grade increased, overall survival (OS) and disease-free survival (DFS) of patients receiving fertility-sparing surgery declined. Neither staging surgery nor laparoscopy of early stage EOC with conservative surgery had a significant effect on OS or DFS. Normal menstruation recommenced after chemotherapy in 89% of the fertility-sparing group. Seventeen pregnancies among twelve patients were achieved by the end of the follow-ups. Conclusions: Fertility-sparing treatment for patients with EOC Stage I Grade 1 could be cautiously considered for young patients. The surgical procedure and surgical route might not significantly influence the prognosis. Standard chemotherapy is not likely to have an evident impact on ovarian function or fertility in young patients.

Key words： Epithelial ovarian carcinoma      Fertility-sparing treatment      Overall survival      Disease-free survival      Pregnancy     
Received: 22 May 2011      Published: 08 October 2011
CLC:  R737.31  
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Jun Hu
Bi-bo Yuan
Li-rong Zhu
Zhi-qing Liang
Yuan-guang Meng
Hong-yan Guo
Peng-peng Qu
Cai-ling Ma
Cong-jian Xu
Cite this article:

Jun Hu, Li-rong Zhu, Zhi-qing Liang, Yuan-guang Meng, Hong-yan Guo, Peng-peng Qu, Cai-ling Ma, Cong-jian Xu, Bi-bo Yuan. Clinical outcomes of fertility-sparing treatments in young patients with epithelial ovarian carcinoma. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2011, 12(10): 787-795.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.B1100166     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2011/V12/I10/787

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