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ZJUS-B
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology)  2006, Vol. 7 Issue (3 ): 10-    DOI: 10.1631/jzus.2006.B0228
    
Effects of combination of irbesartan and perindopril on calcineurin expression and sarcoplasmic reticulum Ca2+-ATPase activity in rat cardiac pressure-overload hypertrophy
Jiang Qing-Jun, Xu Geng, Mao Fei-Fei, Zhu You-Fa
Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China; Department of Cardiology, Ningbo Lihuili Hospital, Ningbo 315041, China; Department of Pharmacy, Children’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310029, China; Department of Pathology, School of Medicine, Zhejiang University, Hangzhou 310009, China
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Abstract  Aim: To observe effects of angiotensin (Ang) II receptor antagonist (AT1) irbesartan and angiotensin-converting enzyme (ACE) inhibitor perindopril on rat myocardium calcineurin expression and sarcoplasmic reticulum Ca2+-ATPase activity in the model of pressure-overload cardiac hypertrophy. Methods: Forty male adult Sprague Dawley rats were divided into 5 groups. One group was treated by sham operation; four groups were myocardium hypertrophy cases caused by banding aortic above renal artery. Drugs were given one week after operation. Group 1: sham group, rats (n=8) were gavaged with normal saline 2 ml/(kg·d) (ig); Group 2: control group, rats (n=8) were treated with normal saline 2 ml/(kg·d) (ig); Group 3: rats (n=8) were given perindopril 2 mg/(kg·d) (ig); Group 4: rats (n=8) were treated with irbesartan 20 mg/(kg·d) (ig); Group 5: rats (n=8) were given irbesartan 20 mg/(kg·d) plus perindopril 2 mg/(kg·d) (ig). Morphometric determination, calcineurin expression and sarcoplasmic reticulum Ca2+-ATPase activity were done at the end of 6 week of drug intervention. Expression of calcineurin in myocardium was detected by immunohistochemistry. Results: Left ventricular mass index (LVMI), transverse diameter of myocardial cell (TDM), calcineurin activity were remarkably decreased after drug intervention and this decrease was most remarkable in the combination drug therapy group. Sarcoplasmic reticulum Ca2+-ATPase activity was increased after drug intervention, especially in the combined drug therapy group. Calcineurin expression in myocardium was remarkably decreased after drug intervention. LVMI was positively correlated with TDM and calcineurin, negatively correlated with sarcoplasmic reticulum Ca2+-ATPase. Conclusion: These data suggest that irbesartan and perindopril inhibit cardiac hypertrophy through the increased activity of sarcoplasmic reticulum Ca2+-ATPase and decreased expression of calcineurin. Their combination had better effects on regressing of ventricular hypertrophy.

Key words： Angiotensin (Ang) II receptor antagonist      Angiotensin-converting enzyme inhibitor      Calcineurin      Sarcoplasmic reticulum Ca2+-ATPase      Pressure overload      Cardiac hypertrophy      Rat     
Received: 24 June 2005     
CLC:  R363  
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Jiang Qing-Jun
Xu Geng
Mao Fei-Fei
Zhu You-Fa
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Jiang Qing-Jun, Xu Geng, Mao Fei-Fei, Zhu You-Fa. Effects of combination of irbesartan and perindopril on calcineurin expression and sarcoplasmic reticulum Ca2+-ATPase activity in rat cardiac pressure-overload hypertrophy. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2006, 7(3 ): 10-.

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http://www.zjujournals.com/xueshu/zjus-b/10.1631/jzus.2006.B0228     OR     http://www.zjujournals.com/xueshu/zjus-b/Y2006/V7/I3 /10

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