Science & Engineering |
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FACILE SYNTHESIS OF 4β-AMINOPODOPHYLLOTOXINS |
CHEN Shao-yuan, YU Yong-ping, GONG Xing-guo, CHEN Yao-zu |
Dept. of Biology; Dept. of Chemistry,Yuquan Campus of Zhejiang University,Hangzhou 310027,China |
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Abstract 4β-amino-4-desoxypodophyllotoxin and 4β-amino-4\'-demethyl-4desoxypodophyllo-toxin were synthesized by reduction of the corresponding 4β-azidopodophyllotoxin derivatives with HCO2NH4/Pd-C in excellent yields under convenient and mild reactive condition.
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Received: 09 March 1998
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