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浙江大学学报(工学版)
J4  2009, Vol. 43 Issue (11): 2028-2033    DOI: 10.3785/j.issn.1008-973X.2009.11.015
生物医学工程     
动物脑电-行为同步记录及分析系统
张韶岷1,2,陈卫东1,3,孙超1,3，于毅1,2,章怀坚1,2,江君1,3,代建华1,3,张恒义2,郑筱祥1,2
（1.浙江大学 求是高等研究院,浙江 杭州 310027； 2.浙江大学 生物医学工程学系,生物医学工程教育部重点实验室,
浙江 杭州 310027； 3.浙江大学 计算机科学与技术学院,浙江 杭州 310027）
Synchronous recording and analyzing system for animal's neuronal activity and behavior
ZHANG Shao-min1,2, CHEN Wei-dong1,3, SUN Chao1,3, YU Yi1,2, ZHANG Huai-jian1,2, JIANG Jun1,3, DAI Jian-hua1,3, ZHANG Heng-yi2, ZHENG Xiao-xiang1,2
(1. Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou 310027, China;
2. Department of Biomedical Engineering, Key Laboratory of Biomedical Engnieering of Ministry of Education, Zhejiang University, Hangzhou 310027, China;
3. College of Computer Science and Technology, Zhejiang University, Hangzhou 310027, China)
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摘要：

设计并构建一套动物脑电-行为同步记录及分析系统,系统主要包括动物行为实验装置、脑电信号与行为图像的同步记录子系统、脑电信号分析和处理子系统.当动物在实验装置中进行特定行为时,同步记录子系统同时记录动物的脑电信号和行为图像,通过分析和处理子系统,提取脑电信号的特征值,为大脑神经活动和行为之间的相关性研究提供实验平台.记录并分析大鼠在进行前肢的“伸-缩”运动时运动皮层的神经元集群活动.实验结果表明,大鼠的初级运动皮层中神经元分布式活动与前肢的动作模式密切相关,通过解读初级运动皮层的神经元集群电信号,可以获得大鼠前肢的运动信息,准确判断和区分前肢不同的动作模式.
Abstract:

This work designed and built a synchronous recording and analyzing system for animals neuronal activity and motor behavior, which composed of experimental apparatus for animals behavior, synchronous recording subsystem, processing and analyzing subsystem. When the animals are performing specific task, the synchronous recorder captures both neuronal signals and behavior images, then the analyzing and processing subsystem extracts the feature values of the neuronal signals. This system provides an experimental platform for researching the correlation between neuronal activities and behaviors. The neuronal population activities were recorded and analyzed when a rat was performing “extend-flex” task. The observation showed that the distributed activity of the primary motor cortex is strongly related with the patterns of forelimb activities. By decoding the neuronal population activity from the primary motor cortex, the motion information of forelimb can be acquired and the action modes can be correctly distinguished and estimated.
出版日期: 2009-11-01
:  R 318  
基金资助:

国家自然科学基金资助项目（30570433）.
通讯作者: 郑筱祥，女，教授.     E-mail: zxx@mail.bme.zju.edu.cn
作者简介: 张韶岷（1977-），男，浙江温州人，讲师，从事神经工程研究.
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引用本文:

张韶岷, 陈卫东, 孙超, 等. 动物脑电-行为同步记录及分析系统[J]. J4, 2009, 43(11): 2028-2033.

ZHANG Shao-Min, CHEN Wei-Dong, SUN Chao, et al. Synchronous recording and analyzing system for animal's neuronal activity and behavior. J4, 2009, 43(11): 2028-2033.

链接本文:

http://www.zjujournals.com/eng/CN/10.3785/j.issn.1008-973X.2009.11.015    或    http://www.zjujournals.com/eng/CN/Y2009/V43/I11/2028

[1] DONOGHUE J P. Connecting cortex to machines: recent advances in brain interfaces [J]. Nature Neuroscience, 2002, 5(Suppl.): 1085-1088．
[2] HATSOPOULOS N, JOSHI J, OLEARY J G. Decoding continuous and discrete motor behaviors using motor and premotor cortical ensembles [J]. Journal of Neurophysiology, 2004, 92(2): 1165-1174．
[3] HATSOPOULOS N G, HARRISON M T, DONOGHUE J P. Representations based on neuronal interactions in motor cortex [J]. Progress in Brain Research, 2001, 130: 233-244．
[4] FUKAYAMA O, MORISHITA Y, SUZUKI T, et al. Estimation of walking speed for controlling vehicle using neural signals from primary motor cortex of rat [C]∥The 2nd International IEEE/EMBS Conference on Neural Engineering. Washington D.C.: IEEE, 2005: 442-445．
[5] ARTEMIADIS P K, SHAKHNAROVICH G, VARGAS-IRWIN C, et al. Decoding grasp aperture from motor-cortical population activity [C]∥ The 3rd International IEEE/EMBS Conference on Neural Engineering. Hawaii: IEEE, 2007: 518-521．
[6] HU J, SI J, OLSON B P, et al. Feature detection in motor cortical spikes by principal component analysis [J]. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2005, 13(3): 256-262．
[7] PEGAN S D. Molecular gating dynamics of the cytoplasmic domains of inwardly rectifying potassium (Kir) channels [D]. San Diego: University of California, 2006: 227-229．
[8] MCLACHLAN G J. Discriminant analysis and statistical pattern recognition [M]. New York: Wiley, 2005: 29-38．
[9] CASSIM F, MONACA C, SZURHAJ W, et al. Does post-movement beta synchronization reflect an idling motor cortex？ [J]. Neuroreport, 2001, 12(17): 3859-3863．
[10] RO J Y, DEBOWY D, LU S, et al. Digital video: a tool for correlating neuronal firing patterns with hand motor behavior [J]. Journal of Neuroscience Methods, 1998, 82(2): 215-231．
[11] OLEARY J G, HATSOPOULOS N G. Early visuomotor representations revealed from evoked local field potentials in motor and premotor cortical areas [J]. Journal of Neurophysiology, 2006, 96(3): 1492-1506．
[12] DONCHIN O, GRIBOVA A, STEINBERG O, et al. Local field potentials related to bimanual movements in the primary and supplementary motor cortices [J]. Experimental Brain Research, 2001, 140(1): 46-55．
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