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工程设计学报
Chinese Journal of Engineering Design  2004, Vol. 11 Issue (4): 192-196    DOI:
    
Fabrication of microneedle array for drug delivery systems
 FU  Xin, JIAO  Feng, XIE  Hai-Bo
State Key Laboratory of Fluid Power Transmission and Control，Zhejiang University，Hangzhou 310027，China
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Abstract  Transdermal drug delivery is limited by the extraordinary barrier properties of the strarum corneum ，the outer skin．Conventional needles insert across this barrier and into deeper tissue to effectively deliver drug，but can lead to infection and cause pain，thereby reducing patient compliance． The authors have microfabricated very short microneedles that are sufficiently long to penetrate through the stratum corneum ，but short enough not to stimulate nerves in deeper tissue and thus should be painless． These microneedle are created with HNA (HNO 3 4-HF +CH3COOH)etching system ，a silicon isotropic wet etching．

Key words： silicon      microtechnology      microfabrication      wet etching      isotropic etching microneedle      transdermal drug delivery system     
Published: 28 August 2004
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FU Xin, JIAO Feng, XIE Hai-Bo. Fabrication of microneedle array for drug delivery systems. Chinese Journal of Engineering Design, 2004, 11(4): 192-196.

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https://www.zjujournals.com/gcsjxb/     OR     https://www.zjujournals.com/gcsjxb/Y2004/V11/I4/192


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关键词： 硅,  微细加工技术,  微加工,  湿法腐蚀,  各项同性腐蚀微针,  透皮给药系统 
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