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工程设计学报  2016, Vol. 23 Issue (6): 612-619    DOI: 10.3785/j.issn.1006-754X.2016.06.014
整机和系统设计     
全自动生化进样系统的设计
刘镇武1, 尚志武1, 黄炎彬2
1. 天津工业大学 天津市现代机电装备技术重点实验室, 天津 300387;
2. 天津市一瑞生物工程有限公司, 天津 300000
Design of full automatic biochemical sampling system
LIU Zhen-wu1, SHANG Zhi-wu1, HUANG Yan-bin2
1. Tianjin Modern Electromechanical Equipment Technology Key Laboratory, Tianjin Polytechnic University, Tianjin 300387, China;
2. Tianjin Era Biology Engineering Co., Ltd., Tianjin 300000, China
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摘要:

医疗检测过程中,传统的人工检测方法效率低、主观误差大、成本高.针对人工检测的缺陷以及生化分析系统高精度、小型化的需求,自主研发了一种全自动生化进样系统.该系统在机械结构上兼具移液和取退吸头的功能,在控制方法上优化了执行机构的控制算法.首先,为满足自动进样系统的实际需求,设计了整个系统的结构和以STM32控制芯片为核心的控制系统;其次,通过论证步进电机的控制算法,决定采用S型曲线控制算法,并对其进行优化和实现,从而提高了系统的控制精度和速度;最后,为进一步提高系统的鲁棒性,对试验数据进行整理和分析,得到了系统的误差补偿曲线和校正方法.结果表明改进后的系统拥有更高的进样精度,满足了更广泛的实际需求,对医疗器械的研发具有指导意义.

关键词: 生化分析仪进样系统STM32S型曲线误差补偿    
Abstract:

In the process of medical examination, the traditional manual detection method has the characteristics of low efficiency, high subjective error and high cost. According to the defects of artificial detection and the requirements of biochemical analysis system with high precision and miniaturization, a full automatic biochemical sampling system was developed. In the mechanical structure, the system had the functions of moving the liquid and taking and withdrawing the suction head. In the control method, the actuator control algorithm was optimized. Firstly, the whole system structure was designed and the control system based on the STM32 control chip was completed to meet the actual needs of the automatic sampling system. Secondly, by demonstrating the stepper motor control algorithm, the S type curve control algorithm was used, and the algorithm was optimized and implemented, thus, the control accuracy and speed was improved. Finally, in order to further improve the robustness of the system, we collated and analyzed the experimental data, and got the system error compensation curve and the method of correction. The results show that the improved system has higher accuracy of sampling, meets the actual needs more extensively, and has guiding significance for the development of medical devices.

Key words: biochemical analyzer    sampling system    STM32    S type curve    error compensation
收稿日期: 2016-04-14 出版日期: 2016-12-28
CLC:  TP29  
基金资助:

天津市科技支撑计划重点项目(16YFZCSY00860).

通讯作者: 尚志武(1977-),男,天津人,正高级工程师,从事智能诊断与动态测控、机电一体化技术、先进检测技术等研究,E-mail:shangzhiwu@126.com.http://orcid.org//0000-0002-7310-0921     E-mail: shangzhiwu@126.com
作者简介: 刘镇武(1990-),男,河南洛阳人,硕士生,从事机械机构研究,E-mail:jikouji@126.com.http://orcid.org//0000-0002-0145-0690
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引用本文:

刘镇武, 尚志武, 黄炎彬. 全自动生化进样系统的设计[J]. 工程设计学报, 2016, 23(6): 612-619.

LIU Zhen-wu, SHANG Zhi-wu, HUANG Yan-bin. Design of full automatic biochemical sampling system. Chinese Journal of Engineering Design, 2016, 23(6): 612-619.

链接本文:

https://www.zjujournals.com/gcsjxb/CN/10.3785/j.issn.1006-754X.2016.06.014        https://www.zjujournals.com/gcsjxb/CN/Y2016/V23/I6/612

[1] 张文昌. 全自动酶免分析系统加样过程监控技术研究[D].北京:北京信息科技大学仪器科学与光电工程学院,2012:1-2. ZHANG Wen-chang. Research on the monitoring and control technology of the whole automatic enzyme immunoassay system[D]. Beijing:Beijing Information Science and Technology University, School of Instrument Science and Opto Electronic Engineering, 2010:1-2.
[2] 朱圣领. 全自动酶免分析仪的工作机理及关键技术的研究[D]. 苏州:苏州大学机电工程学院,2005:11-12. ZHU Sheng-ling. Research on the working mechanism and key technology of automatic enzyme immunoassay analyzer[D]. Zuzhou:Soochow University, School of Mechanical and Electric Engineering, 2005:11-12.
[3] 姚玉峰,路士州,刘亚欣,等.微量液体自动分配技术研究综述[J].机械工程学报,2013,49(14):140-153. YAO Yu-feng, LU Shi-zhou, LIU Ya-xin, et al. Research on the automatic distribution of micro liquid[J]. Journal of Mechanical Engineering, 2013, 49(14):140-153.
[4] 李小丽,王芳,赵美宁.模切机间歇输纸系统位置精度分析[J].工程设计学报,2006,13(5):329-331. LI Xiao-li, WANG Fang, ZHAO Mei-ning. Position precision analysis of intermittent paper feeding system on mould-cutting machine[J]. Chinese Journal of Engineering Design,2006,13(5):329-331.
[5] 李腾. 基于AVR钢轨打磨机自动控制系统的设计与实现[D].北京:北京邮电大学信息与通讯工程学院,2014:22-23. LI Teng. Design and realization of the automatic control system of the rail grinding machine based on AVR[D]. Beijing:Beijing University of Posts and Telecommunications, School of Information and Communication Engineering, 2014:22-23.
[6] 郭宗和,余顺年,马履中,等.新型3-RRC并联机器人机构精度分析[J].工程设计学报,2006,13(2):91-94. GUO Zong-he, YU Shun-nian, MA Lü-zhong, et al. Accuracy analysis of novel 3-RRC parallel robot mechanism[J]. Chinese Journal of Engineering Design, 2006,13(2):91-94.
[7] 刘艳霞,桑兆辉. 基于ARM芯片S3C4510的步进电机加减速控制[J]. 机床与液压,2007, 35(7):180-181. LIU Yan-xia, SANG Zhao-hui. Step motor acceleration and deceleration control based on ARM chip[J]. Machine Tool and Hydraulic, 2007, 35(7):180-181.
[8] 侯艳艳,王洪君,王丽丽. 三轴联动数控雕刻机加减速控制算法的研究[J]. 组合机床与自动化加工技术,2006(7):49-51. HOU Yan-yan, WANG Hong-jun, WANG Li-li. Research on acceleration and deceleration control algorithm of three axis linkage CNC engraving machine[J]. Modular Machine Tool and Automatic Manufacturing Technique, 2006(7):49-51.
[9] 张占立,康春花,郭士军,等.基于单片机的步进电机控制系统[J]. 电机与控制应用,2011,38(3):28-31,50. ZHANG Zhan-li, KANG Chun-hua, GUO Shi-Jun, et al. Based on single-chip stepper motor control system[J]. Electric Machines and Control Application, 2011,38(3):28-31,50.
[10] 黄兆斌,黄云龙,余世明. 几种步进电机加减速方法的对比研究及其应用[J]. 机电工程,2011,28(8):951-953, 974. HUANG Zhao-bin, HUANG Yun-long, YU Shi-ming. Comparative study between several acceleration and deceleration methods on stepper motor and the application[J]. Journal of Mechanical and Electrical Engineering, 2011, 28(8):951-953,974.
[11] 杨超,张冬泉. 基于S曲线的步进电机加减速的控制[J]. 机电工程,2011,28(7):813-817. YANG Chao, ZHANG Dong-quan. Control of acceleration and deceleration of stepping motor based on S curve[J]. Journal of Mechanical and Electrical Engineering, 2011, 28(7):813-817.
[12] 常海涛,祝连庆,娄小平,等. 一种全自动酶免分析仪移液过程评估新方法[J]. 仪器仪表学报,2014, 38(7):1622-1629. CHANG Hai-tao, ZHU Lian-qing, LOU Xiao-ping, et al. A fully automatic enzyme immunoassay analyzer shift liquid process to evaluate the new method instrument[J]. Chinese Journal of Scinetific Instrument, 2014, 38(7):1622-1629.
[13] KAPLIT M.Detection of insufficient sample during aspiration with a pipette:US7634378 B2[P].2009-10-15.
[14] TAKEDA M,KATAGI H,KATO Y,et al.Pipetting apparatus with clot detection:US5540081[P]. 1996-06-30.
[15] 汪朝红,胡良勇,傅忆宾,等. 数字可调移液器校准方法研究[J].中国测试,2011,37(3):23-25. WANG Zhao-hong, HU Liang-yong, FU Yi-bin, et al. Research on calibration method of digital adjustable shift liquid[J]. China Measurement & Test, 2011,37(3):23-25.
[16] ISO Technical Committees. Piston-operated volumetric apparatus Part 6:gravimetric methods for the determination of measurement error:ISO8655-6:2002[S]. German:German Institute for Standardization, 2002:12-13.
[17] 刘志刚,万良晨. 自动进样器的误差分析[J]. 广东技术师范学院学报,2014(3):38-42. LIU Zhi-gang, WAN Liang-chen. Error analysis of automatic sampling device[J]. Journal of Guangdong Polytechnic Normal University, 2014(3):38-42.
[18] 耿耀锋,吴一辉,宣明,等. 小型生化分析仪自动进样系统设计[J].工程设计学报,2008, 15(1):29-32. GENG Yao-feng, WU Yi-hui, XUAN Ming, et al. Design of automatic sampling system for small biochemical analyzer[J]. Chinese Journal of Engineering Design, 2008, 15(1):29-32.

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