Several mineral nutrient elements of plants can reduce Cd availability in soil by precipitation and adsorption, and decrease Cd absorption of plants by the competition between Cd and plant nutrients for the same membrane transporters. Nutrient management is one of the most important agronomic practices for better crop growth. Accordingly, it is regarded as a low cost, short period and high efficient way to alleviate Cd accumulation in crops by proper management of nutrients and proper treatment of the interactions between Cd and plant nutrients. In addition, other agronomic measures and molecular plant breeding, which could modulate the interactions between Cd and plant nutrients, might also be two relatively inexpensive and effective strategies to minimize Cd contamination in crops. The main objective of this review is to highlight how the interactions between mineral nutrient elements and Cd affect the availability of Cd in soil, and the Cd absorption of plants. Examples include that, the competition between Fe, Ca, Zn, Mn and Cd uptake by root can decrease Cd levels in plants, and iron supply prevents Cd uptake by inhibiting iron- regulated transporter1 (IRT1) expression. The strategies of using these interactions to minimize Cd accumulation in the edible parts of crops were also focused in this review. For example, the application of P fertilizer can precipitate with Cd to reduce Cd uptake by plants. In addition, Si and Se fertilizer foliage application can decrease Cd translocation from roots to shoots in plants, thus reducing Cd accumulation in edible organs and improving food safety.