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浙江大学学报（农业与生命科学版）
浙江大学学报(农业与生命科学版)  2015, Vol. 41 Issue (2): 119-124    DOI: 10.3785/j.issn.1008-9209.2014.07.171
生物科学与技术     
器官形态发生探索Ⅰ:生物电与形态发生
赵海平1， 刘振1， 陈广信2， 李春义1*
1.中国农业科学院特产研究所，特种动物分子生物学国家重点实验室，长春 130112;2.广东海洋大学农学院，广东 湛江 524088
Exploration of organ morphogenesisⅠ: Bioelectricity and morphogenesis.
Zhao Haiping1, Liu Zhen1, Chen Guangxin2, Li Chunyi1*
(1. State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China; 2. College of Agriculture, Guangdong Ocean University, Zhanjiang 524088, Guangdong, China)
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摘要： 器官形态发生是生命体发育成其固有的三维立体结构并维持其形状的过程，这个过程需要形态发生信息的指导。形态发生信息包含3个方面：1）位置信息；2）预期模式信息；3）表观遗传信息。形态发生信息的实质及其作用机制是理解形态发生的首要条件。在低等动物中研究发现，生物电作为一个密码系统编码着形态发生，是形态发生信息的实质。该文综述了器官形态发生场与器官形态发生、生物电在编码器官形态发生方面的最新研究进展，并基于日常生活中用电作为密码系统的实例，提出了生命体内存在生物电高级运行方式的假设。相信在不久的将来，随着生物电密码的破解，人为控制器官形态发生将成为现实。
Abstract: Morphogenesis is a biological process that involves the shape development and pattern maintenance of an organism. Morphogenetic information is needed for morphogenetic primordial developing to construct an appropriate three-dimension (3D) structure, which includes three aspects: positional information, prepatterning information, and epigenetic information. The essence and mechanism of morphogenetic information is the primary condition to understand morphogenesis. This paper reviews the latest research progress of morphogenetic field, bioelectricity and organ morphogenesis. Mechanism of organ morphogenesis has not been well understood in life science field. Advances in molecular biology were expected to solve this mystery, but proved to be a failure. Interestingly, recent study showed that organ morphogenesis was regulated by bioelectricity at multiple levels on lower animals, for example: 1) Artificially setting the resting potential in embryonic frog cells can lead to eye formation at any part of amphibian body; 2) bioelectricity can regulate regeneration of tail and ectopic limb formation in Xenopus tadpoles; 3) bioelectricity determines regeneration pattern of amputated planaria fragments on whether head or tail. Therefore, organ fate was obviously determined by bioelectric state of morphogenetic primordia. Bioelectricity is the essence of organ morphogenetic information, which is a landmark advance in this field that the bioelectricity encodes organ morphogenesis. It is an inspiration that electric is used as a signal code in communication for understanding work mechanism of bioelectric code. For example, Morse alphabet and binary, which consist of electrical signal, are used in telegram system and computer system respectively. Nowadays, 3D structures can be made by 3D printer, and the machine can execute commands encoded by binary. The physical process of bioelectricity encoding organ morphogenesis in animal bodies is similar with that of 3D structures made by printer. On basis of those theories, a hypothesis was proposed that complicated bioelectric mode (BM) operation in animal bodies was similar with binary in computer system. Exploration of the signal pathway of BM is the key to crack bioelectricity code. The dream of artificially controlling organ morphogenesis was expected to be realized when the secret code of bioelectricity for organ morphogenesis be cracked in the near future.
出版日期: 2015-03-20
CLC:  Q 954 33  
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赵海平
刘振
陈广信
李春义

引用本文:

赵海平，刘振，陈广信，李春义. 器官形态发生探索Ⅰ:生物电与形态发生[J]. 浙江大学学报(农业与生命科学版), 2015, 41(2): 119-124.

Zhao Haiping, Liu Zhen, Chen Guangxin, Li Chunyi. Exploration of organ morphogenesisⅠ: Bioelectricity and morphogenesis.. Journal of Zhejiang University (Agriculture and Life Sciences), 2015, 41(2): 119-124.

链接本文:

http://www.zjujournals.com/agr/CN/10.3785/j.issn.1008-9209.2014.07.171    或    http://www.zjujournals.com/agr/CN/Y2015/V41/I2/119

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